TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA.

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2024-02-01 Epub Date: 2024-01-07 DOI:10.1134/S160767292370059X

M M Kurshakova, Y A Yakusheva, S G Georgieva

引用次数: 0

Abstract

The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown. We have shown that TREX-2-ORC participates in the nuclear export of histone mRNAs: it associates with histone mRNPs, binds to histone H3 mRNA at the 3'-terminal part of the coding region, and participates in the export of histone mRNAs from the nucleus to the cytoplasm.

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黑腹角雉的 TREX-2-ORC 复合物参与组蛋白 mRNA 的核输出

黑腹滨蝇的 TREX-2-ORC 蛋白复合物是大部分合成的含聚（A）的 mRNA 分子通过核孔从细胞核向细胞质输出的必要条件。然而，该复合体在其他类型 RNA 的输出中的作用仍然未知。我们已经证明，TREX-2-ORC 参与了组蛋白 mRNA 的核输出：它与组蛋白 mRNPs 结合，在编码区的 3'-terminal 部分与组蛋白 H3 mRNA 结合，并参与了组蛋白 mRNA 从细胞核到细胞质的输出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.

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