The effects of microgravity on stem cells and the new insights it brings to tissue engineering and regenerative medicine

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-01-07 DOI:10.1016/j.lssr.2024.01.001

Hong-Yun Nie , Jun Ge , Kai-Ge Liu , Yuan Yue , Hao Li , Hai-Guan Lin , Hong-Feng Yan , Tao Zhang , Hong-Wei Sun , Jian-Wu Yang , Jin-Lian Zhou , Yan Cui

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引用次数: 0

Abstract

Conventional two-dimensional (2D) cell culture techniques may undergo modifications in the future, as life scientists have widely acknowledged the ability of three-dimensional (3D) in vitro culture systems to accurately simulate in vivo biology. In recent years, researchers have discovered that microgravity devices can address many challenges associated with 3D cell culture. Stem cells, being pluripotent cells, are regarded as a promising resource for regenerative medicine. Recent studies have demonstrated that 3D culture in microgravity devices can effectively guide stem cells towards differentiation and facilitate the formation of functional tissue, thereby exhibiting advantages within the field of tissue engineering and regenerative medicine. Furthermore, We delineate the impact of microgravity on the biological behavior of various types of stem cells, while elucidating the underlying mechanisms governing these alterations. These findings offer exciting prospects for diverse applications.

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微重力对干细胞的影响及其为组织工程和再生医学带来的新启示

传统的二维（2D）细胞培养技术在未来可能会发生改变，因为生命科学家已经普遍认识到三维（3D）体外培养系统能够精确模拟体内生物学。近年来，研究人员发现微重力设备可以解决与三维细胞培养相关的许多难题。干细胞是多能细胞，被认为是再生医学的一种有前途的资源。最近的研究表明，在微重力设备中进行三维培养能有效引导干细胞分化，促进功能组织的形成，从而在组织工程和再生医学领域显示出优势。此外，我们还描述了微重力对各类干细胞生物学行为的影响，同时阐明了这些改变的内在机制。这些发现为各种应用提供了令人兴奋的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464