Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-07-13 DOI:10.4314/ahs.v23i2.19

Qiang Wang, Wenmin Qin, Wei Gao, Kai Zhao, Xiaohong Pan, Xiaofei Jiang, Juan Zhao

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引用次数: 0

Abstract

Background: To analyse the correlation between vaginal flora and cervical immune function of HPV-infected patients with cervical cancer. Methods: Six hundred females with genital tract infections treated in Xuzhou Hospital of Traditional Chinese Medicine from January 2014 to December 2016 were selected and divided into a high-risk HPV group (n=246) and a control group (n=354). The vaginal flora and human T lymphocyte subsets (CD3+, CD4+, CD8+) were detected. Multivariate logistic regression analysis was performed to explore the risk factors for HPV infection. Results: The numbers of CD4+ and CD4+/CD8+ T cells of the high-risk HPV group were significantly lower than those of the control group (P<0.05). The two groups had similar numbers of CD3+ and CD8+ T cells. In the high-risk HPV group, the positive rates of Lactobacillus, Chlamydia trachomatis, Mycoplasma hominis, mycetes, Ureaplasma urealyticum and bacterial vaginosis were significantly higher than those of the control group (P<0.05). There was no significant difference in the positive rates of trichomonads between the two groups. Multivariate logistic regression analysis revealed that C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection (P<0.05). Conclusion: High-risk HPV infection in patients with cervical cancer was associated with vaginal flora and immune function. C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection. Keywords: Cervical cancer; human papilloma virus; immune function; vaginal flora.

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人乳头瘤病毒感染的宫颈癌患者阴道菌群与宫颈免疫功能之间的相关性

背景：分析感染 HPV 的宫颈癌患者阴道菌群与宫颈免疫功能之间的相关性。方法：对徐州市中医院收治的 600 例生殖道感染女性患者进行研究：选取2014年1月至2016年12月在徐州市中医院接受治疗的600例生殖道感染女性患者，分为高危HPV组（n=246）和对照组（n=354）。检测阴道菌群和人类T淋巴细胞亚群（CD3+、CD4+、CD8+）。为探究 HPV 感染的风险因素，进行了多变量逻辑回归分析。结果显示高危HPV组的CD4+和CD4+/CD8+ T细胞数量明显低于对照组（P<0.05）。两组的 CD3+ 和 CD8+ T 细胞数量相似。在高危 HPV 组中，乳酸杆菌、沙眼衣原体、人型支原体、霉菌、解脲支原体和细菌性阴道病的阳性率明显高于对照组（P<0.05）。两组的滴虫阳性率无明显差异。多变量逻辑回归分析显示，沙眼衣原体和尿道脲原体是高危 HPV 感染的独立危险因素（P<0.05）。结论宫颈癌患者的高危HPV感染与阴道菌群和免疫功能有关。沙眼衣原体和尿路感染脲原体是高危HPV感染的独立危险因素。关键词：宫颈癌；人乳头瘤病毒宫颈癌；人乳头瘤病毒；免疫功能；阴道菌群

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.