Postoperative Oral Iodine-131 Combined with Nutritional Management for the Management of Thyroid Cancer: A Meta-Analysis

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-08-29 DOI:10.37290/ctnr2641-452x.22:1-7

Yifan Liu, Jintang Jia

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引用次数: 0

Abstract

Iodine nutrition plays a central role in the normal physiological function of the thyroid gland, and it is a major factor in thyroid hormone synthesis. A meta-analysis was used to measure the efficacy of oral iodine-131 combined with nutritional management in thyroid cancer patients after surgery. Computer searches were conducted on various databases, with the search time limited to January 2011 to December 2021, and the literature retrieved was limited to randomized controlled trials. Data extraction and quality evaluation were performed for the included literature, and meta-analysis was conducted by RevMan 5.3 software. A total of 9 literatures were obtained, all in English, with a sample size of 10,219 cases, containing 6,845 cases in the study group (oral iodine-131 + nutritional management) together with 3,374 cases in the control group (oral iodine-131 alone). The study group received oral administration of iodine-131 and nutritional management (low-iodine diet). The outcomes of the meta-analysis revealed that the clinical symptoms of thyroid cancer patients were improved after oral administration of iodine-131 after surgery. No statistical differences could be observed in the incidence of adverse reactions, recurrence rate, or metastasis rate of outcome indicators. To sum up, oral administration of iodine-131 combined with nutritional management has certain clinical effects in patients with thyroid cancer after surgery, but due to the limited literature included and low data quality, the conclusions of this study still need to be further verified.

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术后口服碘-131与营养管理相结合治疗甲状腺癌：元分析

碘营养在甲状腺的正常生理功能中起着核心作用，是甲状腺激素合成的主要因素。本研究采用荟萃分析法来衡量甲状腺癌患者术后口服碘-131结合营养管理的疗效。在多个数据库中进行了计算机检索，检索时间限于2011年1月至2021年12月，检索到的文献仅限于随机对照试验。对纳入的文献进行数据提取和质量评估，并使用RevMan 5.3软件进行荟萃分析。共获得 9 篇英文文献，样本量为 10,219 例，其中研究组（口服碘-131 + 营养管理）6,845 例，对照组（单独口服碘-131）3,374 例。研究组接受口服碘-131 和营养管理（低碘饮食）。荟萃分析结果显示，甲状腺癌患者术后口服碘-131后，临床症状得到改善。在不良反应发生率、复发率和转移率等结果指标上，未发现统计学差异。综上所述，甲状腺癌术后患者口服碘131联合营养管理具有一定的临床效果，但由于纳入的文献有限，数据质量不高，本研究的结论仍有待进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.