Functional and structural annotation of an uncharacterized protein A0A077Z4I5 from Trichuris trichiura

Abstract

: Trichuris trichiura is a human parasite belonging to the nematode phylum. It has a genome of 75.2 Mb size that contains more than 9500 genes. Many of these are still uncharacterized proteins. Here, we have tried to annotate a protein bearing Uniprot accession id A0A077Z4I5 using various in silico tools. The amino acid sequence of this protein was subjected to various softwares which demonstrated it to be a Cysteine-knot protein. The motif search revealed the presence of this highly conserved domain, which is believed to be responsible for host parasite interaction and evasion of host immune system by the parasitic nematode. The report of this protein in human parasite T. trichiura is significant as it has not homolog in humans and can be a valid drug target.