GC-MS analysis of Orthosiphon comosus Wight ex Benth

Q4 Biochemistry, Genetics and Molecular Biology

Biochemical and Cellular Archives Pub Date : 2023-09-01 DOI:10.51470/bca.2023.23.2.1269

K. Subramonian, A. S. Ganthi, K. Namasivayam

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Abstract

: India is one of the world’s 12 biodiversity centers with the presence of over 45000 different plants species. India’s diversity is unmatched due to the presence of 16 different agro-climatic zones, 10 vegetation zones, 25 biotic provinces and 426 biomes (habitats of specific species). Orthosiphon comosus Wight ex Benth. has very little previous record of use in traditional medicine. Orthosiphon comosus is commonly known as “Pavazha thulasi” in Tamil and is a medium sized shrub and endemic aromatic plant to Kalakad Mundanthurai Tiger Reserve Forest (KMTR), in South India. Orthosiphon comosus Wight ex Benth. is an erect shrub, 3 - 5 feet high. The main objective of the current study was carried out to identify the bioactive chemical constituents present in the ethanol fraction of shade dried leaf sample of Orthosiphon comosus . In GC/MS analysis fifteen constituents were identified. GC/MS chromatogram of O. comosus ethanol extract gives two prominent peaks with retention time 31.32 and 32.43 indicating the presence of two bioactive compounds such as 9,19-Cyclolanost-24-en-ol, acetate (36)- and 13.27-Cyclounon-3-one. The identified compounds were reported as antioxidant, antimicrobial and anti-tumour properties. Identification of various bioactive compounds in the extract of O. comosus dried leaves warrants further biological and pharmacological studies.

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Orthosiphon comosus Wight ex Benth 的气相色谱-质谱分析

:印度是世界上 12 个生物多样性中心之一，拥有 45000 多种不同的植物物种。由于印度拥有 16 个不同的农业气候区、10 个植被区、25 个生物省和 426 个生物群落（特定物种的栖息地），其多样性无与伦比。Orthosiphon comosus Wight ex Benth.在传统医学中的使用记录很少。Orthosiphon comosus 在泰米尔语中俗称 "Pavazha thulasi"，是一种中等大小的灌木，也是南印度卡拉卡德蒙丹图赖老虎保护区森林（KMTR）特有的芳香植物。Orthosiphon comosus Wight ex Benth.是一种直立灌木，高 3-5 英尺。本研究的主要目的是鉴定阴干的 Orthosiphon comosus 叶样乙醇部分中的生物活性化学成分。通过气相色谱/质谱分析，确定了 15 种成分。O. comosus 乙醇提取物的气相色谱/质谱色谱图显示出两个显著的峰，保留时间分别为 31.32 和 32.43，表明存在两种生物活性化合物，如 9,19-Cyclolanost-24-en-ol, acetate (36)- 和 13.27-Cyclounon-3-one 。已鉴定的化合物具有抗氧化、抗菌和抗肿瘤特性。从 O. comosus 干叶提取物中鉴定出的各种生物活性化合物值得进行进一步的生物学和药理学研究。

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Biochemical and Cellular Archives Biochemistry, Genetics and Molecular Biology-Biochemistry

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期刊介绍： Biochemical and Cellular Archives – publishes original full length full length research papers, short communications and review articles in all areas of agricultural, biological and medical sciences. Emphasis will be given to manuscript which present novel finding pertinent to the biochemical basis of cellular structure and function as well as mechanism of cellular organelles. Investigations directed towards electron microscopy and localization of biomolecules in cells / tissues are particularly encouraged. The articles for the following broad areas of biological sciences will be considered for publications: ● Cellular Structure, Physiology and Biochemistry. ● Bacteriology, Virology and Toxicology. ● Light and electron microscopy and histochemistry. ● Immunology and molecular biology. ● Pathology.