Association of Obesity with Prostate Cancer at Time of Biopsy: A MultiCentre 10-Year Retrospective Study

International Journal of Research in Oncology Pub Date : 2023-09-30 DOI:10.33425/2833-0390.1020

C. Kamadjou, D. Eyongeta, Quincy Jones Shumbang, Annie Kameni Wadeu, B. Amougou, F. Angwafo

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Abstract

Background and Aim: The incidence of Prostate cancer (PCa) is on the rise in Cameroon, making it the most commonly diagnosed cancer amongst men. Factors, such as obesity, smoking, and the consumption of high fat diet have been reported to play a role in the aetiology and progression of cancers in general. However, the exact relationship between obesity and prostate cancer in Africans is still poorly described. The present study aimed to evaluate the association between obesity as measured by the body mass index (BMI) and high-grade prostate cancer in Cameroonians. Methods: This was a retrospective analyses of the clinical records of 300 consecutive men who underwent transrectal ultrasound-guided core needle prostate biopsy between January 2010 and January 2020. Patients were grouped as obese (BMI ≥30kg/m²) and non-obese (BMI <30kg/m²) and binary logistic regression modelling was used to compare the association between obesity and patient characteristics, such as age, digital rectal examination (DRE) findings, prostate specific antigen (PSA) level, prostate volume, PSA density, and Gleason score (GS). Results: The mean age at diagnosis of PCa was 65.46 ± 8.54 years (Range: 34-89 years), the mean BMI was 28.93 ± 4.57 kg/m² (Range: 18.35-42.37 kg/m²), and the median total PSA level was 44.2 ng/ml. In total, 142 men (47.3%) were obese and biopsies detected high-grade prostate cancer in 160 men (63.3%). Obese men were significantly younger and had a higher risk (OR= 2.74, p <0.001) of having high-grade PCa compared to nonobese men. Furthermore, 94 obese men (58.75%) had high-grade PCa. Obese men had higher age-adjusted PSA densities (P<0.001), while there was no statistical difference in DRE findings (OR= 1.06, p= 0.225). Conclusion: This study demonstrated that obesity is associated with a higher risk of high-grade prostate cancer. This risk is more pronounced among younger patients and DRE findings are not influenced by BMI.

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活检时肥胖与前列腺癌的关系：一项多中心 10 年回顾性研究

背景和目的：在喀麦隆，前列腺癌（PCa）的发病率呈上升趋势，成为男性中最常见的癌症。据报道，肥胖、吸烟和高脂肪饮食等因素在癌症的病因和发展过程中起着重要作用。然而，非洲人的肥胖与前列腺癌之间的确切关系仍鲜为人知。本研究旨在评估喀麦隆人以体重指数（BMI）衡量的肥胖与高级别前列腺癌之间的关系。研究方法本研究对2010年1月至2020年1月期间接受经直肠超声引导核心针前列腺活检的300名男性患者的临床记录进行了回顾性分析。患者被分为肥胖（体重指数≥30kg/m²）和非肥胖（体重指数<30kg/m²）两组，并使用二元逻辑回归模型比较肥胖与患者特征（如年龄、数字直肠检查（DRE）结果、前列腺特异性抗原（PSA）水平、前列腺体积、PSA密度和格里森评分（GS））之间的关系。研究结果确诊 PCa 时的平均年龄为 65.46 ± 8.54 岁（范围：34-89 岁），平均体重指数为 28.93 ± 4.57 kg/m²（范围：18.35-42.37 kg/m²），总 PSA 水平中位数为 44.2 纳克/毫升。共有 142 名男性（47.3%）肥胖，活组织检查发现 160 名男性（63.3%）患有高级别前列腺癌。与非肥胖男性相比，肥胖男性明显更年轻，患高级别前列腺癌的风险更高（OR= 2.74，P <0.001）。此外，94 名肥胖男性（58.75%）患有高级别 PCa。经年龄调整后，肥胖男性的 PSA 密度更高（P<0.001），而 DRE 结果无统计学差异（OR= 1.06，P= 0.225）。结论这项研究表明，肥胖与罹患高级别前列腺癌的风险较高有关。这种风险在年轻患者中更为明显，而 DRE 结果不受体重指数的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Research in Oncology

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