RECURRENT ADRENOCORTICAL CARCINOMA– A CASE REPORT

Abstract

Incidence of Adrenocortical Carcinoma approximately 1 to 2 (1, 2) case/ million Population per year. It represents only 0.02% of all Neoplasm. It has two peak of incidence 0-5 years and 40 to 50 years of age. (3) It predominantly occurs in Females with Male: Female ratio of (1:1.5-2.5). (4,5) Some studies suggested proliferative effects of oestrogen hormone on malignant adrenal cells (3) The National Institute of Health office of Rare Disease, research defines rare disease as having prevalence of less than 2,00,000 (two lakh) patients in the United States of America (8). A 37-year-old female presented with pain in abdomen for the last 3 months, she had undergone surgery in 2019, Histopathology report came as adrenocortical tumor. Biopsy was done which had shown malignant neoplasm, Immunohistochemistry report has confirmed as Adrenocortical tumour. Melan-A diffuse moderate strong positive in tumour cells. Adrenocortical carcinoma is found to be more common in the Children (11) Similar to our case report Else and colleagues also reported unilateral involvement with the normal contra lateral adrenal gland and female preponderance. The adjuvant therapies are advised to decrease the chances of recurrence. For unresectable or metastatic disease treatment is advisable with palliative purpose.