A Low Cost, Flexible Atmospheric Pressure Plasma Jet Device With Good Antimicrobial Efficiency

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Fellype do Nascimento;Aline da Graça Sampaio;Noala Vicensoto Moreira Milhan;Aline Vidal Lacerda Gontijo;Philipp Mattern;Torsten Gerling;Eric Robert;Cristiane Yumi Koga-Ito;Konstantin Georgiev Kostov
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引用次数: 0

Abstract

Plasma sources suitable to generate low-temperature plasmas has been fundamental for the advances in plasma medicine. In this research field, plasma sources must comply with stringent conditions for clinical applications. The main requirement to be met is the patient and operator’s safety and the ethical requirement of effectivity, which encompasses the electrical regulations, potential device toxicity, and effectiveness in relation to the desired treatment. All these issues are addressed by the German prestandard DIN SPEC 91315:2014–06 (DINSpec), which deals with the safety limits, risk assessment, and biological efficacy of plasma sources aimed for medical applications. In this work, a low cost, user-friendly, and flexible atmospheric pressure plasma jet (APPJ) device was characterized following the DINSpec guidelines. The device, which is still under development, proved to be safe for medical applications. It is capable of producing an APPJ with low patient leakage current and ultraviolet emission, gas temperature lower than 40 °C, production of harmful gases within the safety limits and low cytotoxicity. The most differentiating feature is that the device presented good antimicrobial efficacy even operating at frequency of the order of just a few hundred Hz, a value below that of most devices reported in the literature.
具有良好抗菌效率的低成本、灵活的常压等离子喷射装置
适合产生低温等离子体的等离子体源是等离子体医学发展的基础。在这一研究领域,等离子源必须符合临床应用的严格条件。需要满足的主要要求是病人和操作者的安全以及有效性的道德要求,其中包括电气法规、潜在的设备毒性以及与所需治疗相关的有效性。德国预标准 DIN SPEC 91315:2014-06(DINSpec)解决了所有这些问题,该标准涉及医疗应用等离子源的安全限制、风险评估和生物功效。在这项工作中,我们根据 DINSpec 指南,对一种低成本、用户友好且灵活的常压等离子体喷射(APPJ)设备进行了鉴定。该设备仍在开发中,但已证明可安全用于医疗应用。它能够生产出患者漏电流和紫外线辐射低、气体温度低于 40 {/deg}C、有害气体产生量在安全范围内、细胞毒性低的 APPJ。最与众不同的是,该设备即使在几百赫兹的频率下工作,也能产生良好的抗菌效果,这一数值低于文献中报道的大多数设备。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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