Autoinmunidad en pacientes pediátricos de una región de Colombia, tras un pico de SARS-CoV-2

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2024-10-01 DOI:10.1016/j.rcreu.2023.08.001

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引用次数: 0

Abstract

Introduction

With the onset of the 2019 coronavirus pandemic, there was an increase in the number of reported cases of autoimmune manifestations in the midst of the disease and new cases of autoimmunity after infection.

Objective

To correlate the rate of positive tests of SARS-CoV-2 with the rate of new diagnoses of autoimmune disease in paediatric patients of the department of Huila (Colombia), between March 2020 and September 2021.

Methods

The socio-demographic characterization of the subjects diagnosed with autoimmune disease and of the cases of SARS-CoV-2 was performed; an analysis of the monthly trend of events was performed and a correlation model was applied between the rate of SARS-CoV-2 diagnosis and the rate of autoimmune diseases during the study period.

Results

A total of 94 cases of autoimmune disease were diagnosed, with an average age of 8.3 years, most were girls and belonged to the urban area and the subsidized regimen, and immune thrombocytopenic purpura was the most common diagnosis. In addition, 4,303 cases of SARS-CoV-2 were detected, mostly adolescents, from urban areas and the contributory system. Finally, it was evidenced that the highest rate of autoimmune disease was reported just after the highest peak of SARS-CoV-2.

Conclusions

This study did not show a statistical correlation between the rate of SARS-CoV-2 and the rate of diagnoses of autoimmune disease; however, it showed an enormous peak of autoimmunity after the highest peak of infection in paediatric patients of the department during the first eighteen months of the pandemic.

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哥伦比亚某地区的儿科患者在 SARS-CoV-2 峰值之后出现自身免疫现象

摘要: 随着2019年冠状病毒大流行的到来，在疾病期间报告的自身免疫表现病例和感染后新出现的自身免疫病例数量有所增加。方法对诊断为自身免疫性疾病的受试者和 SARS-CoV-2 病例进行社会人口学特征描述；对每月事件趋势进行分析，并在研究期间应用 SARS-CoV-2 诊断率与自身免疫性疾病发病率之间的相关模型。结果共诊断出 94 例自身免疫性疾病，平均年龄为 8.3 岁，大多数为女孩，属于城市地区和补贴方案，免疫性血小板减少性紫癜是最常见的诊断。此外，还发现了 4 303 例 SARS-CoV-2 病例，其中大部分是青少年，来自城市地区和补助系统。结论这项研究没有显示出 SARS-CoV-2 感染率与自身免疫性疾病诊断率之间存在统计学上的相关性；但是，它显示出在大流行的前 18 个月中，该部门的儿科病人在感染最高峰之后出现了一个巨大的自身免疫高峰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.