Seroprevalence of VZV and HSV-2 Antibodies among Women of Childbearing Age Referring to Health Centres of Mashhad, Iran: The Need for Consideration of VZV Vaccination Program

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
M. Youssefi, Farnaz Zahedi Avval, Hoda Ghasabzadeh, Majid khadem-Rezaiyan
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Abstract

Infections with herpes simplex virus type 2 (HSV-2) and varicella-zoster virus (VZV) are associated with serious maternal and neonatal health consequences. The literature review reveals a research gap regarding the seroprevalence of HSV-2 and VZV among women of reproductive age in Mashhad, Northeast of Iran. The present study aims to evaluate the seroprevalence of these viruses among a group of women in Mashhad, Iran. Sera were collected by health center personnel using a cluster sampling method from healthy women with specific age characteristics residing in three distinct socioeconomic regions of the city. The participants, aged 20–35, were divided into three groups (20–25, 26–30, and 31–35 years). The levels of VZV and HSV-2 IgG antibodies were evaluated using commercial ELISA kits. Subsequently, the results were analyzed using SPSS software. A total of 93 women were included in the study. Anti-HSV-2 IgG antibody was detected in 3 out of 93 participants (7.5%), while anti-VZV IgG antibody was found positive in 80 out of 93 individuals (83.3%). The HSV-2 positive cases were concurrently positive for the VZV antibody. There was no significant difference in the positivity of anti-HSV-2 and anti-VZV antibody positivity within age groups or socioeconomic status (P > 0.05). The high seroprevalence of VZV among nonvaccinated participants indicates a widespread presence of the virus and underscores its potentially serious impact on community health. Therefore, it is recommended that a VZV vaccination program be considered by the health system. Furthermore, the reactivation of latent HSV-2, whether symptomatic or asymptomatic, during pregnancy should not be disregarded as a life-threatening threat.
伊朗马什哈德卫生中心转诊的育龄妇女中 VZV 和 HSV-2 抗体的血清流行率:考虑实施 VZV 疫苗接种计划的必要性
单纯疱疹病毒 2 型(HSV-2)和水痘-带状疱疹病毒(VZV)感染与严重的孕产妇和新生儿健康后果有关。文献综述显示,伊朗东北部马什哈德育龄妇女的 HSV-2 和 VZV 血清流行率方面存在研究空白。本研究旨在评估这些病毒在伊朗马什哈德一群妇女中的血清流行率。 血清由保健中心的工作人员采用集群抽样的方法从居住在该市三个不同社会经济区域、具有特定年龄特征的健康女性中采集。参与者年龄在 20-35 岁之间,分为三组(20-25 岁、26-30 岁和 31-35 岁)。使用商业 ELISA 试剂盒评估了 VZV 和 HSV-2 IgG 抗体的水平。随后,使用 SPSS 软件对结果进行分析。 共有 93 名妇女参与了研究。93 名参与者中有 3 人(7.5%)检测到抗 HSV-2 IgG 抗体,而 93 人中有 80 人(83.3%)抗 VZV IgG 抗体呈阳性。HSV-2阳性病例中同时存在VZV抗体阳性。抗 HSV-2 和抗 VZV 抗体阳性率在不同年龄组和社会经济地位之间没有明显差异(P > 0.05)。 未接种疫苗的参与者中 VZV 血清阳性率很高,这表明病毒广泛存在,并凸显了其对社区健康的潜在严重影响。因此,建议卫生系统考虑实施 VZV 疫苗接种计划。此外,怀孕期间潜伏的 HSV-2 无论是有症状还是无症状,都不应该被视为威胁生命的病毒而被忽视。
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来源期刊
International Journal of Preventive Medicine
International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
4.80%
发文量
107
期刊介绍: International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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