Clinical Factors Associated With Extreme Sleep Apnea in Patients Living at High Altitude (Bogotá D.C., Colombia): A Case–Control Study

Q3 Medicine

Revista Colombiana de Psiquiatria Pub Date : 2025-03-01 DOI:10.1016/j.rcp.2023.10.002

Franklin Escobar-Córdoba , Jorge Rey de Castro , Charles Huamaní

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引用次数: 0

Abstract

Objective

To assess risk factors associated with extreme obstructive sleep apnea (OSA) in patients living at high altitudes.

Methods

A case–control study was conducted using data collected between 2016 and 2017 in patients who lived in Bogotá D.C. (2640 m above sea level) and were treated at FUNDASUVICOL. Participants: Six hundred twenty patients met the inclusion criteria: 110 had moderate OSA, 144 had severe OSA, 203 had very severe OSA and 163 had extreme OSA (cases). The controls–cases ratio was 3:1. Measurements: Participants’ data were obtained from their medical records. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals.

Results

The bivariate analysis showed that the following variables were associated with extreme OSA: morbid obesity (ORcrude = 32.22; 95% CI = 9.10–114.1), high blood pressure (HBP) (ORcrude = 2.40; 95% CI = 1.66–3.46), snoring (ORcrude = 4.69; 95% CI = 1.42–15.45), body mass index (BMI) (ORcrude = 1.14; 95% CI = 1.10–1.18), neck circumference (ORcrude = 1.13; 95% CI = 1.08–1.18) and age (ORcrude = 1.02; 95% CI = 1.01–1.04). Somehow, after performing a multivariate regression analysis adjusted by age, gender, morbid obesity, snoring, HBP and neck circumference, it was determined that only morbid obesity (OR = 8.34; 95% CI = 2.04–34.05) and neck circumference (OR = 1.09; 95% CI = 1.01–1.16) are risk factors for extreme OSA.

Discussion

Morbid obesity and neck circumference were significantly associated with extreme OSA. Therefore, losing weight and improving anthropometric measurements should be considered in OSA treatment to reduce the severity of symptoms and to improve polysomnographic parameters in these patients.

查看原文本刊更多论文

生活在高海拔地区（哥伦比亚波哥大特区）的患者极度睡眠呼吸暂停的相关临床因素：病例对照研究

目的探讨高海拔地区极端阻塞性睡眠呼吸暂停（OSA）患者的危险因素。方法采用2016 - 2017年收集的数据，对居住在波哥大（海拔2640 m）并接受FUNDASUVICOL治疗的患者进行病例对照研究。参与者：620例患者符合纳入标准：中度OSA 110例，重度OSA 144例，极重度OSA 203例，重度OSA 163例。对照病例比为3:1。测量方法：参与者的数据来自他们的医疗记录。采用Logistic回归模型计算调整后的优势比和95%置信区间。结果双因素分析显示，与重度OSA相关的变量有：病态肥胖(ORcrude = 32.22；95% CI = 9.10-114.1)，高血压（HBP） (ORcrude = 2.40；95% CI = 1.66-3.46)、打鼾(ORcrude = 4.69；95% CI = 1.42-15.45)，身体质量指数（BMI） (ORcrude = 1.14；95% CI = 1.10-1.18)、颈围(ORcrude = 1.13；95% CI = 1.08-1.18)和年龄(ORcrude = 1.02；95% ci = 1.01-1.04)。然而，在对年龄、性别、病态肥胖、打鼾、血压和颈围等因素进行多元回归分析后，我们发现只有病态肥胖(OR = 8.34；95% CI = 2.04-34.05)和颈围(OR = 1.09；95% CI = 1.01-1.16)为重度OSA的危险因素。病态肥胖和颈围与重度OSA显著相关。因此，在OSA治疗中应考虑减肥和改善人体测量，以减轻症状的严重程度，改善这些患者的多导睡眠图参数。

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来源期刊

Revista Colombiana de Psiquiatria Medicine-Psychiatry and Mental Health

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Revista Colombiana de Psiquiatría (RCP) is a quarterly official publication of Colombian Psychiatry Association (March, June, September and December) and its purpose is to spread different the knowledge models that currently constitute the theoretical and practical body of our specialty. Psychiatrists, psychiatric residents, non psychiatric physicians, psychologists, philosophers or other health professionals or persons interested in this area can take part in the magazine. This journal publishes original works, revision or updating articles, case reports of all psychiatry and mental health areas, epistemology, mind philosophy, bioethics and also articles about methodology of investigation and critical reading.