Mycobacterium tuberculosis infection among children under fifteen years of age: A population-based study in Indonesia

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-01 DOI:10.4103/1995-7645.388387

Made Agus Nurjana, A. Laksono, I Kadek Wartana, Vidyanto, Gunawan, A. Nursafingi, Samarang, H. Anastasia, Kristina Tobing, Anis Nurwidayati, Octaviani

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Abstract

Objective: To assess the prevalence of Mycobacterium (M.) tuberculosis infection and its associated risks in children under fifteen years of age. Methods: Based on secondary data from the 2018 Indonesian Basic Health Survey (RISKESDAS 2018), this cross-sectional study employed M. tuberculosis infection in children as a dependent variable and age level, sex, region, location, family case positive, and smoking as independent variables. Geospatial analysis was applied to show the prevalence of M. tuberculosis infection and multivariate regression was performed to analyze the risk factors of getting the infection among children under 15 years of age. Results: Prevalence ranges of M. tuberculosis infection among children aged 0-14 years, babies (age <12 months), toddlers (age 12-59 months), and children aged between 5 and 14 years were 0.03% to 0.57%, 0% to 0.64%, 0% to 0.78%, and 0.01% to 0.53%, respectively in Indonesia. A high prevalence of M. tuberculosis infection among children under 15 years of age was found in Papua and other provinces, such as Kalimantan and Java. Contacting with tuberculosis family members was positively associated with M. tuberculosis infection in children as shown by multivariate logistic regression (OR 8.94; 95% CI 5.4-14.6, P<0.05). Conclusions: Contacting with family member who has tuberculosis is related with M. tuberculosis infection among children in Indonesia. Therefore, screening the household for contact with tuberculosis patients is a preventive treatment for children.

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十五岁以下儿童的结核分枝杆菌感染情况：印度尼西亚的一项人口研究

目的评估 15 岁以下儿童结核分枝杆菌感染率及其相关风险。方法：基于 2018 年印度尼西亚基本健康调查（RISAS）的二手数据：基于 2018 年印度尼西亚基本健康调查（RISKESDAS 2018）的二手数据，本横断面研究采用儿童结核分枝杆菌感染作为因变量，年龄水平、性别、地区、地点、家庭病例阳性和吸烟作为自变量。应用地理空间分析显示结核杆菌感染率，并进行多元回归分析 15 岁以下儿童感染结核杆菌的风险因素。结果印度尼西亚0-14岁儿童、婴儿（年龄小于12个月）、幼儿（年龄12-59个月）和5-14岁儿童的结核杆菌感染率范围分别为0.03%-0.57%、0%-0.64%、0%-0.78%和0.01%-0.53%。巴布亚以及加里曼丹和爪哇等其他省份发现，15 岁以下儿童的结核杆菌感染率较高。多变量逻辑回归（OR 8.94; 95% CI 5.4-14.6，P<0.05）显示，与结核病家庭成员接触与儿童感染结核杆菌呈正相关。结论与患有结核病的家庭成员接触与印度尼西亚儿童感染结核杆菌有关。因此，筛查与肺结核患者接触过的家庭是对儿童的一种预防性治疗。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.