Caracterización de los pacientes menores de 18 años con nefritis lúpica en el Hospital Pablo Tobón Uribe y en el Hospital San Vicente Fundación de la ciudad de Medellín, entre 2008 y 2017

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2024-10-01 DOI:10.1016/j.rcreu.2023.09.005

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引用次数: 0

Abstract

Introduction

The kidney is one of the organs frequently affected in systemic lupus erythematosus (40-60%); the manifestations are variable, from a silent pattern to the irreversible impairment of renal function.

Objetives

•
To characterize patients under 18 years of age with a diagnosis of lupus nephritis treated at the Pablo Tobón Uribe Hospital and San Vicente Fundación Hospital during the years 2006 to 2017.
•
Establish the frequency of lupus nephritis in patients diagnosed with childhood systemic lupus erythematosus.
•
Describe the general, sociodemographic, clinical and paraclinical characteristics, as well as histopathological characteristics, immunosuppressive treatment and complications such as chronic kidney disease, high blood pressure, need for renal replacement therapy and death in patients diagnosed with lupus nephritis.
•
Explore the association between lupus nephritis with a histological pattern defined as moderate or severe and chronic kidney disease, arterial hypertension, need for renal replacement therapy and death.

Materials and methods

Descriptive study with retrospective information in a group of patients under 18 years of age with a diagnosis of lupus nephritis, attended in two referral centres of the city of Medellin between 2008 and 2017. Clinical records of patients who met the inclusion criteria were reviewed.

Results

The median age was 13 years, with predominance in females. The majority had renal involvement at the time of diagnosis of lupus. Histological class IV was the most frequent (48%). Age under 10 years, absence of response to induction therapy, and histological class IV, were related to the development of chronic kidney disease (> 60 ml/min/1.73 m²).

Conclusions

Renal involvement was higher in this study. Age, class IV, and non-response to induction were associated with impaired renal function.

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2008 年至 2017 年间，麦德林市巴勃罗-托邦-乌里韦医院和圣维森特基金会医院中 18 岁以下狼疮肾炎患者的特征。

导言：肾脏是系统性红斑狼疮（40%-60%）中经常受累的器官之一；其表现多种多样，从无声无息的模式到不可逆转的肾功能损害，不一而足。-描述狼疮肾炎患者的一般、社会人口学、临床和辅助临床特征，以及组织病理学特征、免疫抑制治疗和并发症，如慢性肾病、高血压、需要肾脏替代治疗和死亡。-材料与方法对 2008 年至 2017 年间在麦德林市两家转诊中心就诊的一组 18 岁以下诊断为狼疮性肾炎的患者进行回顾性资料描述性研究。结果中位年龄为13岁，女性居多。大多数患者在确诊狼疮时肾脏已受累。组织学分级为IV级的患者最多（48%）。年龄不足 10 岁、对诱导治疗无反应、组织学分级 IV 级与慢性肾病（60 毫升/分钟/1.73 平方米）的发展有关。年龄、IV级和对诱导治疗无反应与肾功能受损有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.