Modern etiopathogenetic, clinicopathological and therapeutic aspects of lichen planus

Abstract

Objective — to analyze modern views on the etiopathogenesis, clinical course and approaches to the complex therapy of lichen planus, and to determine promising directions for further research that will contribute to the expansion of ideas about the mechanisms of development and optimization of the treatment of this dermatosis. Materials and methods. Based on the analysis of modern data from special literature and according to the results of our own preliminary studies, the expediency of further in-depth studies of the state of microcirculation and microbiocenosis in skin lesions of patients with lichen planus was determined. Results and discussion. Violations of microcirculation and changes in microbiocenosis in foci of skin lesions in patients with lichen planus are important links in the pathogenesis of this dermatosis, and can also affect the severity of its clinical course. Conclusions. So far, the etiopathogenetic and clinicopathological aspects of lichen planus have been studied in detail, which allows us to evaluate the mechanisms of development, clinical course and approaches to the treatment of this dermatosis in a new way.The state of microcirculation and changes in the microbiocenosis in foci of skin lesions in patients with lichen planus require further in-depth research. The results of our preliminary studies indicate that microcirculation disorders and microbiocenosis changes in the skin lesions of patients with lichen planus affect the nature and severity of the clinical course of this dermatosis.Further in-depth studies of microcirculatory disorders and changes in microbiocenosis in foci of skin lesions in patients with lichen planus will allow to optimize complex therapy and expand the understanding of the pathogenesis of this dermatosis.