Modern etiopathogenetic, clinicopathological and therapeutic aspects of lichen planus

K.A. Manvelova
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Abstract

Objective — to analyze modern views on the etiopathogenesis, clinical course and approaches to the complex therapy of lichen planus, and to determine promising directions for further research that will contribute to the expansion of ideas about the mechanisms of development and optimization of the treatment of this dermatosis. Materials and methods. Based on the analysis of modern data from special literature and according to the results of our own preliminary studies, the expediency of further in-depth studies of the state of microcirculation and microbiocenosis in skin lesions of patients with lichen planus was determined. Results and discussion. Violations of microcirculation and changes in microbiocenosis in foci of skin lesions in patients with lichen planus are important links in the pathogenesis of this dermatosis, and can also affect the severity of its clinical course. Conclusions. So far, the etiopathogenetic and clinicopathological aspects of lichen planus have been studied in detail, which allows us to evaluate the mechanisms of development, clinical course and approaches to the treatment of this dermatosis in a new way.The state of microcirculation and changes in the microbiocenosis in foci of skin lesions in patients with lichen planus require further in-depth research. The results of our preliminary studies indicate that microcirculation disorders and microbiocenosis changes in the skin lesions of patients with lichen planus affect the nature and severity of the clinical course of this dermatosis.Further in-depth studies of microcirculatory disorders and changes in microbiocenosis in foci of skin lesions in patients with lichen planus will allow to optimize complex therapy and expand the understanding of the pathogenesis of this dermatosis.
扁平苔藓的现代病因学、临床病理学和治疗学问题
目的--分析有关扁平苔藓的发病机制、临床过程和综合治疗方法的现代观点,并确定有希望的进一步研究方向,这将有助于拓展有关这种皮肤病的发病机制和优化治疗的思路。 材料和方法。根据对专门文献中现代数据的分析,并根据我们自己的初步研究结果,确定了进一步深入研究扁平苔藓患者皮损中微循环和微生物增生状态的适宜性。 结果与讨论扁平苔藓患者皮损灶的微循环破坏和微生物增殖变化是该皮肤病发病机制中的重要环节,也会影响其临床病程的严重程度。 结论迄今为止,我们已对扁平苔藓的病因学和临床病理学方面进行了详细研究,这使我们能够以一种新的方式评估这种皮肤病的发病机制、临床病程和治疗方法。我们的初步研究结果表明,扁平苔藓患者皮损处的微循环障碍和微生物菌群变化会影响这种皮肤病的性质和临床病程的严重程度。对扁平苔藓患者皮损灶的微循环障碍和微生物菌群变化的进一步深入研究将有助于优化复合疗法,扩大对这种皮肤病发病机制的认识。
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