Prospects for the use of Lipster Mint cream in the complex treatment of herpes zoster

O.P. Shevchenko, P. V. Bardov, S.N. Razdaibiedin
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Abstract

Objective — to investigate the clinical efficacy of Lipster Mint cream in the complex treatment of patients with herpes zoster. Materials and methods. The study included 15 patients (11 women and 4 men) with acute herpes zoster. The age of the patients ranged from 38 to 70 years. The patients had severe clinical symptoms (typical vesicular rash, itching of varying intensity, burning sensation, intense pain along the affected nerves and sleep disturbance). The localization of pathological foci was unilateral: in 12 patients on the skin of the trunk, in 1 patient on the buttock and in 2 patients on the skin of the thigh. All patients reported a decrease in quality of life due to the disease. The complex treatment included Valavir, one of the valacyclovir drugs, according to the recommended regimens, which was administered orally in 1000 mg tablets three times a day for 7 days. Acute herpes-associated pain and heartburn were relieved with analgesics and topical application of Lipster Mint cream, manufactured by Farmak (Ukraine), which contains acyclovir 5 % and menthol. A distinctive advantage of Lipster Mint is that it contains the highest dose of acyclovir permitted for topical products — 5 %, as well as menthol which cools and reduces itching. The effectiveness of treatment of herpes zoster was assessed by the dynamics of clinical symptoms and subjective feelings on the 2nd, 5th and 10th days of treatment. Results and discussion. As a result of the treatment, positive dynamics of all clinical manifestations was achieved. Inflammatory phenomena such as swelling and hyperemia of the skin significantly decreased, the appearance of fresh herpes rash stopped within 24 hours, body temperature normalized on the 2—3rd day, general condition improved, pain and discomfort in the affected areas significantly decreased, partial epithelialization of erosions and the appearance of crusts were observed on the 5—7th day. With the topical application of Lipster Mint, under the influence of menthol, from the first minutes of application, patients significantly reduced the sensations of burning, tingling and pain in the areas of skin lesions. Conclusions. Despite the available arsenal of specific and non-specific antiherpetic drugs, treatment of patients suffering from herpes zoster continues to be an urgent medical problem that requires further improvement and individualized approach. Our clinical observations indicate the effectiveness of the systemic drug Valavir and the topical drug Lipster Mint cream in the complex treatment of herpes zoster, which makes it possible to reduce postherpetic neuralgia in the areas of skin lesions and improve the quality of life of patients.
利普斯特薄荷膏在带状疱疹复合治疗中的应用前景
目的--研究 Lipster 薄荷膏在带状疱疹患者复合治疗中的临床疗效。 材料和方法研究对象包括 15 名急性带状疱疹患者(11 名女性和 4 名男性)。患者年龄从 38 岁到 70 岁不等。患者均有严重的临床症状(典型的水泡状皮疹、不同程度的瘙痒、烧灼感、沿受累神经的剧烈疼痛和睡眠障碍)。病灶位于单侧:12 名患者位于躯干皮肤,1 名患者位于臀部,2 名患者位于大腿皮肤。所有患者都报告说,疾病导致生活质量下降。综合治疗包括按照推荐方案口服伐昔洛韦(伐昔洛韦药物之一),每次 1000 毫克,每天三次,连续 7 天。急性疱疹引起的疼痛和胃灼热可通过镇痛剂和局部使用由 Farmak(乌克兰)公司生产的 Lipster Mint 乳膏来缓解,该乳膏含有 5 % 的阿昔洛韦和薄荷醇。Lipster Mint 软膏的独特优势在于,它含有外用产品允许的最高剂量阿昔洛韦(5%)以及薄荷醇,薄荷醇可以降温和止痒。带状疱疹的治疗效果通过治疗第 2、5 和 10 天的临床症状和主观感受的动态变化进行评估。 结果与讨论治疗的结果是,所有临床表现都得到了积极的改善。皮肤肿胀和充血等炎症现象明显减轻,新鲜疱疹在 24 小时内停止出现,体温在第 2-3 天恢复正常,全身状况有所改善,患处疼痛和不适明显减轻,第 5-7 天观察到糜烂部分上皮化和结痂出现。在薄荷醇的作用下,局部涂抹 Lipster Mint 后,从涂抹的最初几分钟开始,患者皮损部位的烧灼感、刺痛感和疼痛感就明显减轻了。 结论尽管现有的特异性和非特异性抗带状疱疹药物种类繁多,但带状疱疹患者的治疗仍然是一个亟待解决的医学问题,需要进一步改进并采取个性化的治疗方法。我们的临床观察结果表明,在带状疱疹的综合治疗中,全身用药瓦拉韦和局部用药利普斯特薄荷膏的疗效显著,可以减轻皮损部位的带状疱疹后遗神经痛,提高患者的生活质量。
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