Anti-lipidemic and protein restoration potential of Monodora myristica (Gaertn.) in rats fed with cassava containing crude oil

IF 1.3 Q4 FOOD SCIENCE & TECHNOLOGY

Foods and Raw Materials Pub Date : 2023-11-17 DOI:10.21603/2308-4057-2024-2-602

J. Okpoghono, Jonah Kanayo Ukperegbulem, Udoka Bessie Igue

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引用次数: 0

Abstract

Consumption of cassava meal affected by crude oil has significant effects on lipid and protein metabolism. The hepatoprotective action of spices is mostly attributed to the suppression of lipid oxidation and protein breakdown. This study examined the protein restoration and anti-lipidemic potential of Monodora myristica (Gaertn.) in rats fed with cassava contaminated with crude oil. The research involved 36 albino rats separated into six groups (n = 6). Group 1 (control) consumed cassava without crude oil. Group 2 received cassava with crude oil. Groups 3, 4, and 5 fed on cassava with crude oil and various extracts of M. myristica, i.e., aqueous, ethanol, and diethyl ether, respectively. Group 6 received non-ionic synthetic surfactant Tween 80. The experiment relied on standard methods. Blood serum and liver obtained from the rats of Group 2 showed a significant (p < 0.05) increase in total cholesterol, low density lipoprotein cholesterol, triacylglycerol, and malondialdehyde, as well as a decrease in total protein, albumin, and high-density lipoprotein cholesterol. The groups that received M. myristica extracts showed a significant increase (p < 0.05) in total protein, albumin, and high-density lipoprotein cholesterol. They also had lower total cholesterol, low density lipoprotein cholesterol, triacylglycerol, and malondialdehyde as compared to Group 2, which dieted on cassava contaminated with crude oil without additives. In this research, crude oil-contaminated cassava affected proteins and lipids in rats. Diethyl ether extract of M. myristica demonstrated the best anti-lipidemic and protein restoration.

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用含原油的木薯喂养大鼠时，Monodora myristica（Gaertn.）

食用受原油影响的木薯粉对脂质和蛋白质代谢有显著影响。香料的保肝作用主要归因于抑制脂质氧化和蛋白质分解。本研究考察了用受原油污染的木薯喂养的大鼠体内 Monodora myristica (Gaertn.) 的蛋白质恢复和抗脂质代谢潜力。研究涉及 36 只白化大鼠，分为 6 组（n = 6）。第 1 组（对照组）食用不含原油的木薯。第 2 组食用含原油的木薯。第 3、第 4 和第 5 组分别食用含原油的木薯和肉豆蔻的各种提取物，即水溶液、乙醇和二乙醚。第 6 组使用非离子合成表面活性剂吐温 80。实验采用标准方法。第 2 组大鼠的血清和肝脏显示总胆固醇、低密度脂蛋白胆固醇、三酰甘油和丙二醛显著增加（p < 0.05），总蛋白、白蛋白和高密度脂蛋白胆固醇减少。接受肉豆蔻萃取物治疗的组，总蛋白、白蛋白和高密度脂蛋白胆固醇显著增加（p < 0.05）。与第二组相比，它们的总胆固醇、低密度脂蛋白胆固醇、三酰甘油和丙二醛含量也更低，而第二组则以受原油污染的木薯为食，不含添加剂。在这项研究中，受原油污染的木薯影响了大鼠的蛋白质和脂质。肉豆蔻的二乙醚提取物显示出最佳的抗脂质和蛋白质恢复效果。

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来源期刊

Foods and Raw Materials FOOD SCIENCE & TECHNOLOGY-

CiteScore

3.70

自引率

20.00%

发文量

审稿时长

24 weeks

期刊介绍： The journal «Foods and Raw Materials» is published from 2013. It is published in the English and German languages with periodicity of two volumes a year. The main concern of the journal «Foods and Raw Materials» is informing the scientific community on the works by the researchers from Russia and the CIS, strengthening the world position of the science they represent, showing the results of perspective scientific researches in the food industry and related branches. The main tasks of the Journal consist the publication of scientific research results and theoretical and experimental studies, carried out in the Russian and foreign organizations, as well as on the authors'' personal initiative; bringing together different categories of researchers, university and scientific intelligentsia; to create and maintain a common space of scientific communication, bridging the gap between the publications of regional, federal and international level.