Conservative Wound Treatment in DMT2 Patients Using Honey

Putu Pradnyasanti Laksmi, Made Ratna Saraswati, Ratna Rayeni Natasha Rooseno, Made Ratih Santi Devinta, Agus Santosa
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Abstract

Background : The number of diabetic patients in Indonesia is on the rise. In contrast to typical wounds in non DMT2 patients, chronic wounds in DMT2 patients heal more slowly, which makes it difficult to achieve complete primary wound healing. Thus, surgery is frequently required to achieve optimal healing. Patients' physical condition, age, comorbidities, and financial circumstances such as high medical costs frequently limiting patients from receiving comprehensive care, resulting alternative treatments are required to treat chronic wounds in DMT2 patients whom prefer conventional medications, addressing all circumstances. Honey, in addition to having fructose compounds, which has the benefit of increasing glucose homeostasis and insulin response, resulting in lower insulin and plasma glucose levels, also has been shown to contain anti-inflammatory and antimicrobial substances that aid in wound healing. Thus, it may be an alternative therapy for chronic wound in DMT2 patients. Methods : A Case-series studies of four DMT2 patients who were referred to Plastic and Reconstructive Outpatient ward with chronic wound were evaluated on a monthly basis following conservative treatment using Nusantara local honey-coated gauze. Result : Secondary wound healing, which can be assessed from the epithelialization process started from the peri-wound area has been obtained through monthly observations. Conclusion : Honey is used as an alternative therapy for patients with diabetic foot ulcers due to its anti-microbial and anti-inflammatory properties in the wound healing process. Furthermore, honey is considered less expensive and more affordable alternative for patients with co-morbidities that is impossible to operate, or with financial limitations. Keywords: DMT2, Chronic wound, Honey
使用蜂蜜对 DMT2 患者的伤口进行保守治疗
背景:印度尼西亚的糖尿病患者人数不断增加。与非 DMT2 患者的典型伤口相比,DMT2 患者的慢性伤口愈合更慢,因此很难实现伤口的完全愈合。因此,经常需要通过手术来达到最佳愈合效果。患者的身体状况、年龄、合并症和经济状况(如高昂的医疗费用)经常限制患者接受全面护理,因此需要采用替代疗法来治疗偏好传统药物的 DMT2 患者的慢性伤口,以应对各种情况。蜂蜜除了含有果糖化合物,能增强葡萄糖稳态和胰岛素反应,从而降低胰岛素和血浆葡萄糖水平外,还含有有助于伤口愈合的抗炎和抗菌物质。因此,它可能是治疗 DMT2 患者慢性伤口的替代疗法。 方法:对四名因慢性伤口转诊至整形外科门诊病房的 DMT2 患者进行病例系列研究,在使用涂有 Nusantara 本地蜂蜜的纱布进行保守治疗后,每月进行一次评估。 结果:通过每月的观察,可以从伤口周围的上皮化过程评估伤口的二次愈合情况。 结论:蜂蜜在伤口愈合过程中具有抗微生物和消炎特性,因此可作为糖尿病足溃疡患者的替代疗法。此外,蜂蜜还被认为是成本较低、更经济实惠的替代疗法,可用于无法进行手术或经济条件有限的并发症患者。 关键词DMT2 慢性伤口 蜂蜜
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