The impact of activation of lipid peroxidation and correctors of calcium-phosphorus metabolism on the condition of periodontal tissues in experimental periodontitis

Yu. V. Verevkina, Z. K. Shamanova, A. Ovsyannikova, S. Sirak, A. Arutyunov, N. I. Bykova, E. Sirak
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Abstract

Relevance. The activation of lipid peroxidation in ultrastructural damage to the oral cells and tissues and maintaining periodontal inflammation plays a crucial role in periodontitis development. There is also evidence of the positive role of some calcium-phosphorus metabolism correctors on the condition of inflamed periodontal tissues. Thus, studying the impact of activation of lipid peroxidation and calcium-phosphorus metabolism correctors in chronic periodontitis treatment is of undoubted theoretical and practical interest. The study developed an experimental model of chronic periodontitis, which helped to investigate the effectiveness of therapy with teriparatide (parathormone) and ethylmethylhydroxypyridine succinate (Mexidol).Purpose. The study aimed to investigate the impact of activation of lipid peroxidation and calcium-phosphorus metabolism correctors on the periodontium condition in an experimental model of chronic periodontitis.Material and methods. An experimental study included 48 white laboratory male rats weighing 230-280 grams using the author's experimental periodontitis model. Result processing utilized a specialized complex of histological, immunohistochemical and biochemical research methods.Results. Lipid peroxides proved to play a crucial role in the development and progression of chronic periodontitis. The therapy carried out in the main group of animals is a factor initiating the acceleration of restructuring metabolic processes of periodontium cell membrane structures to activate ion transport and increase the activity of membrane-bound enzymes that block the chain reaction of oxygen molecule transgeneration from precursor cells with the formation of aldehydes, peroxides and ketones.Conclusion. The study results substantiate the need for additional prescription of antioxidants and calcium-phosphorus metabolism correctors to maintain the balance of antiradical and antiperoxide compounds.
激活脂质过氧化和钙磷代谢纠正剂对实验性牙周炎牙周组织状况的影响
相关性。在口腔细胞和组织的超微结构损伤中,脂质过氧化的激活和牙周炎症的维持在牙周炎的发展中起着至关重要的作用。也有证据表明,一些钙磷代谢纠正剂对发炎牙周组织的状况有积极作用。因此,研究激活脂质过氧化和钙磷代谢纠正剂对慢性牙周炎治疗的影响无疑具有理论和实践意义。该研究建立了一个慢性牙周炎实验模型,有助于研究特立帕肽(对羟基苯磺酸)和琥珀酸乙基甲基羟基吡啶(美施多)的治疗效果。该研究旨在探讨激活脂质过氧化和钙磷代谢纠正剂对慢性牙周炎实验模型牙周状况的影响。实验研究包括 48 只体重 230-280 克的白色实验雄性大鼠,采用作者的实验性牙周炎模型。结果处理采用了组织学、免疫组化和生化研究的专业复合方法。事实证明,脂质过氧化物在慢性牙周炎的发生和发展过程中起着至关重要的作用。在主要动物群体中进行的治疗是加速牙周细胞膜结构新陈代谢过程的一个因素,以激活离子传输,提高膜结合酶的活性,从而阻断氧分子从前体细胞转生并形成醛、过氧化物和酮的链式反应。研究结果证明,有必要增加抗氧化剂和钙磷代谢纠正剂的处方,以维持抗自由基和抗过氧化化合物的平衡。
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