The impact of activation of lipid peroxidation and correctors of calcium-phosphorus metabolism on the condition of periodontal tissues in experimental periodontitis

Abstract

Relevance. The activation of lipid peroxidation in ultrastructural damage to the oral cells and tissues and maintaining periodontal inflammation plays a crucial role in periodontitis development. There is also evidence of the positive role of some calcium-phosphorus metabolism correctors on the condition of inflamed periodontal tissues. Thus, studying the impact of activation of lipid peroxidation and calcium-phosphorus metabolism correctors in chronic periodontitis treatment is of undoubted theoretical and practical interest. The study developed an experimental model of chronic periodontitis, which helped to investigate the effectiveness of therapy with teriparatide (parathormone) and ethylmethylhydroxypyridine succinate (Mexidol).Purpose. The study aimed to investigate the impact of activation of lipid peroxidation and calcium-phosphorus metabolism correctors on the periodontium condition in an experimental model of chronic periodontitis.Material and methods. An experimental study included 48 white laboratory male rats weighing 230-280 grams using the author's experimental periodontitis model. Result processing utilized a specialized complex of histological, immunohistochemical and biochemical research methods.Results. Lipid peroxides proved to play a crucial role in the development and progression of chronic periodontitis. The therapy carried out in the main group of animals is a factor initiating the acceleration of restructuring metabolic processes of periodontium cell membrane structures to activate ion transport and increase the activity of membrane-bound enzymes that block the chain reaction of oxygen molecule transgeneration from precursor cells with the formation of aldehydes, peroxides and ketones.Conclusion. The study results substantiate the need for additional prescription of antioxidants and calcium-phosphorus metabolism correctors to maintain the balance of antiradical and antiperoxide compounds.