Analysis of variation of serum CEA, SCC, CYFRA21-1 in patients with lung cancer and their diagnostic value with EBUS-TBNA

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-11-25 DOI:10.5937/jomb0-37083

YanJia Du, Ya Wen, JieYu Huang

引用次数: 0

Abstract

Objective: To explore the variation of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1) and squamous cell carcinoma (SCC) antigen in patients with lung cancer (LC) and their diagnostic value with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Methods: Selection of 150 patients with suspected lung malignant lesions as the research objects was to analyze the diagnostic value of serum tumor marker test and EBUS-TBNA joint detection for LC. Results: The AUC of joint examination to diagnose LC and identify pathological types of LC was elevated vs. alone detection of each index. Conclusions: Serum CYFRA21-1, SCC and CEA conjugating with EBUS-TBNA are provided with diagnostic value for LC and identified value for pathological types of LC.

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肺癌患者血清 CEA、SCC、CYFRA21-1 的变化及其与 EBUS-TBNA 的诊断价值分析

目的探讨肺癌患者血清癌胚抗原（CEA）、细胞角蛋白 19 片段（CYFRA21-1）和鳞状细胞癌抗原（SCC）的变化及其与支气管内超声引导下经支气管针吸术（EBUS-TBNA）的诊断价值。研究方法选择150例疑似肺部恶性病变患者作为研究对象，分析血清肿瘤标志物检测和EBUS-TBNA联合检测对肺癌的诊断价值。结果联合检查诊断 LC 和鉴别 LC 病理类型的 AUC 均高于单独检测各项指标。结论血清 CYFRA21-1、SCC 和 CEA 与 EBUS-TBNA 联合检测对 LC 具有诊断价值，对 LC 的病理类型具有鉴别价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.