Pharmacological and Evidence-based Review of Euphorbia neriifolia Linn. (Snuhi): An Upavisha; A Strong Purgative; Exigencies to Verify its Potential to Act as an Anthelminthic Drug Especially in Paediatric Age Group in Local Regions of India Specifically in Chhattisgarh

Sonia Singh, Mukta Bariha, Neha Ghritlahre, Neeraj Agrawal, Nagendra Singh Chauhan, Satyawati Rathia, Lowkesh Chandravanshi
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Abstract

Euphorbia neriifolia Linn. ( Snuhi ) (Euphorbiacea family) is a traditional medicine which is included under multiple catagories such as Upavisha, Purgatives and Anthelminthic drugs. Preferably, an anthelminthic agent should have comprehensive deed, high fraction of rehabilitation with a single analeptic hit, denuded noxiousness to the host and should be economical. Even the intricacy like retching, wobbliness and bowel interruption have been shown by the prevalent drugs like piperazine particles. High consequence of the existing drugs and hostility of the parasites to their action sanction the hunt for revived anthelminthic molecules. In the ritualistic remedy implementation, the genesis of many worthwhile drugs is found and to evaluate denizenlore healing herb for their proclaimed anthelminthic virtue, several researchers have undertaken studies. Reinforced governance integrated with Chemical command of helminthes has been the important world-wide worm constraint tactics. Still, global multiplying resistance of gastrointestinal trichostronglides of household petty ruminants hostile to accustomed antihelminthes. [1,2] The expertise of molding employ of even a solitary Drug with their sorting and amalgam to escort a concluding upgraded outcome is Yukti. Not forgetting the safety and fruitfulness of the medicament, it is the fundamental notion of empirical drug lay out. This review describes the key information related to botanical description of E. neriifolia , phytochemistry, pharmacological actions, its purification, clinical studies and better utilization as anthelminthic-purgative package. The author emphasizes the need for evidence-based clinical studies to expand Snuhi pharmacological activities
对Euphorbia neriifolia Linn.(Snuhi)的药理学和循证审查:Upavisha;一种强效镇痛药;验证其作为驱虫药(尤其是在印度恰蒂斯加尔邦当地儿童中)的潜力的必要性
Euphorbia neriifolia Linn.(Snuhi)(大戟科)是一种传统药物,被归入多种类别,如 Upavisha、Purgatives 和 Anthelminthic drugs。抗虫药最好具有全面的作用,一次镇痛即可达到较高的康复率,对宿主无毒性,并且经济实惠。目前流行的药物如哌嗪颗粒,甚至会出现反胃、摇摆和肠道中断等复杂症状。现有药物的高药效和寄生虫对这些药物作用的敌意促使人们寻找新的驱虫分子。在仪式疗法的实施过程中,我们发现了许多有价值的药物的起源,为了评估寄生虫治疗草药所宣称的驱虫功效,一些研究人员已经开展了相关研究。对蠕虫的强化治理与化学控制相结合,一直是世界范围内制约蠕虫的重要策略。尽管如此,全球范围内家庭小反刍动物胃肠道三代寄生虫的抗药性仍在不断增加,这与习惯的抗蠕虫药物是相敌对的。[1,2]即使是单独使用一种药物,其分类和混合以护送最终升级结果的专业技术也是 Yukti。不要忘记药物的安全性和有效性,它是经验性药物布局的基本概念。本综述介绍了与 E. neriifolia 的植物学描述、植物化学、药理作用、纯化、临床研究以及作为驱虫药包更好地利用有关的关键信息。作者强调有必要开展循证临床研究,以扩大斯努希的药理活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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