Chemical composition, antibacterial and antioxidant activities of essential oils from Ccyphostemma adenocaule and Ziziphus spinachristi

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-29 DOI:10.4314/bcse.v38i1.13

Hadush Gebrehiwot, A. Dekebo, Kebede Shenkute, Urgessa Ensermu, Milkyas Endale

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Abstract

In the present work, the chemical composition, antibacterial and antioxidant potencies of essential oils (EOs) extracted from the leaves and roots of Cyphostemma adenocaule and Ziziphus spinachristi were evaluated. Hydrodistillation was used to extract the EOs and the chemical compositions were analyzed by GC-MS. The antibacterial activity of the EOs were evaluated against four bacterial strains by agar disc diffusion method. Moreover, the antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay method. Perillyl alcohol (13.08%) and phytone (12.64%) were the major compounds detected in the leaves and roots of Cyphostemma adenocaule respectively. Whereas, nootkatone was the principal compound detected in the leaves (30.12%) and roots (26.52%) of Ziziphus spinachristi. The antibacterial activity results showed that, the EOs of Cyphostemma adenocaule and Ziziphus spinachristi displayed the highest inhibition zones against Streptococcus pyogenes (13.67 ± 0.34 and 12.67 ± 0.10 mm respectively) at 10 mg/mL. The antioxidant activity of the EOs were also promising, and the strongest IC50 value (4.15 µg/mL) was calculated for Ziziphus spinachristi (leaves). Thus, the antibacterial and antioxidant properties of the EOs enlighten the use of these plants for the aforementioned activities and as a common ingredients in cosmetic applications. KEY WORDS: Essential oils, Antibacterial activity, Antioxidant activity, Cyphostemma adenocaule, Ziziphus Bull. Chem. Soc. Ethiop. 2024, 38(1), 167-186. DOI: https://dx.doi.org/10.4314/bcse.v38i1.13

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Ccyphostemma adenocaule 和 Ziziphus spinachristi 精油的化学成分、抗菌和抗氧化活性

本研究评估了从 Cyphostemma adenocaule 和 Ziziphus spinachristi 的叶和根提取的精油（EOs）的化学成分、抗菌性和抗氧化性。采用水蒸馏法提取精油，并通过气相色谱-质谱分析其化学成分。采用琼脂盘扩散法评估了 EO 对四种细菌菌株的抗菌活性。此外，还采用 2,2-二苯基-1-苦基肼（DPPH）自由基清除法评估了其抗氧化性。在 Cyphostemma adenocaule 的叶片和根中分别检测到的主要化合物是 Perillyl 醇（13.08%）和植物酮（12.64%）。而 Nootkatone 是在 Ziziphus spinachristi 的叶片（30.12%）和根部（26.52%）中检测到的主要化合物。抗菌活性结果表明，在 10 毫克/毫升的浓度下，Cyphostemma adenocaule 和 Ziziphus spinachristi 的环氧乙烷对化脓性链球菌的抑制面积最大（分别为 13.67 ± 0.34 毫米和 12.67 ± 0.10 毫米）。环氧乙烷的抗氧化活性也很有希望，计算出的最强 IC50 值（4.15 µg/mL）为刺五加（叶片）。因此，精油的抗菌和抗氧化特性为这些植物用于上述活动以及作为化妆品的常用成分提供了启示。关键词：精油、抗菌活性、抗氧化活性、Cyphostemma adenocaule、Ziziphus Bull.Chem.Soc.2024, 38(1), 167-186.DOI: https://dx.doi.org/10.4314/bcse.v38i1.13

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.