Relationship of CK-MB Levels with Troponin T in Patient with Coronary Heart Disease at Siloam Hospital Jambi

Abstract

Background: Coronary heart disease (CHD) is one of the cardiovascular diseases which is the highest cause of death in the world. CHD occurs due to the build-up of cholesterol plaque which causes narrowing of the arteries. CHD is characterized by an increase in biomarkers, especially cardiac troponin and Creatine Kinase enzyme activity. The aim of this research is to determine the relationship between CK-MB and Troponin T in CHD patients. Method: The type of this research is descriptive study with a cross sectional approach. The population of this study was all patients who had been clinically diagnosed with CHD by doctors at Siloam Jambi Hospital according to their medical records. The sampling technique used was a total sample technique that met the inclusion and exclusion criteria. To analyze the relationship between variables, a parametric statistical test is used, namely the Pearson correlation test. Result: The results of the study show the average value of CK-MB activity = 46.12 IU/L and Troponin T = 359.53 ng/L. The Pearson correlation test analysis showed that there was a significant relationship between CK-MB and Troponin T (p <0.00001), and the correlation coefficient (r) is 0.636. Conclusion: The activity of the CK-MB enzyme and the levels of Troponin T enzymes have a strong relationship in CHD patients at Siloam Hospital Jambi.