Overview of Monocyte to Hdl Cholesterol Ratio (MHR) in Patients With Coronary Heart Disease (CHD)

Abstract

Background: Coronary Heart Disease (CHD) is a disease caused by plaque that accumulates in the coronary arteries, causing narrowing or blockage of blood flow that supplies oxygen (O2) to the heart muscle. Monocytes accumulate in myocardial tissue experiencing hypoxia and play a role in the formation of atherosclerotic plaque. On the other hand, High-Density Lipoprotein (HDL) is known to reduce the accumulation of macrophages and prevent oxidized cholesterol from entering the artery walls. In the process of healing CHD, the number of monocytes decreases and HDL-cholesterol increases. This study aims to show the potential of the monocyte to HDL Cholesterol ratio as a marker for the prognosis of CHD patients. Method: This study used a case-control research design with a research sample of 50 CHD patients and 50 MCU patients at Bhayangkara Hospital, Jambi City. Result: From the results of the examination, the average monocyte cell count was 461.5 cells/μL, HDL-Cholesterol= 48.1 mg/dL and MHR value= 9.6. Meanwhile, in MCU patients, monocytes were 398 cells/μL, HDL-Cholesterol= 50.4 mg/dL and MHR value= 8.1. Conclusion: The MHR value of CHD patients was significantly higher than that of MCU patients. MHR appears to have good potential in the prognosis of CHD patients.