Dynamic Patterns of Monocyte Lymphocyte Ratio (MLR) in Pulmonary Tuberculosis Patients During Treatment: Insights from Jambi City Health Center

Abstract

Background: Pulmonary Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis (M.tb) bacteria. The occurrence of infection is closely related to immune response. An increase in monocytes and lymphocytes is one of the active immune responses. An increase or decrease in the ratio of these two cells can describe the healing process of TB disease.This study was conducted with the aim to determine the decrease in the Ratio of Monocyte Lymphocyte Ratio (MLR) based on the length of treatment in patients with TB. Method: This type of research is descriptive research with a cross sectional approach with a variable length of treatment. Cross sectional approach with variable length of treatment. This research was conducted in  February-June 2023 with a total sample of 40 TB patients from several Puskesmas in Jambi City. Results: From the research that has been done on TB patients, the average results are as follows The average MLR based on the length of treatment in the initial stage for ≤ 2 months is 0.55; the average MLR in the advanced stage for > 2 months is 0.36; the results of the MLR T test based on the length of treatment with a p-value = 0.36. T test results based on length of treatment with a p-value = 0.129 (p>0.05), there is no significant difference in MLR in patients with pulmonary TB. Conclusion: Significant difference in MLR in patients with pulmonary TB based on length of treatment