Clinical characteristic and prognosis of amyotrophic lateral sclerosis in a cohort of Thai patients

IF 0.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurology Asia Pub Date : 2023-12-01 DOI:10.54029/2023yjk

Narupat Suanprasert, Narumon Tiawijit, Walaiphan Watcharachinnawong, Metha Apiwattanakul, Thanes Termglinjan, Saharat Aungsumart, Chaichana Sinthuwong, Arada Rojana-udomsart

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引用次数: 0

Abstract

Background & Objective: Clinical course and prognosis in amyotrophic lateral sclerosis (ALS) patients were highly variable. The information in the Thai population is still lacking. This study aimed to determine the clinical association with disease progression and prognostic factors in ALS in Thailand. Methods: This prospective cohort study evaluated 62 patients who has a diagnosis of ALS and followed up at Neurological Institute of Thailand between January 2014 and December 2018. These patients were classified into an alive group and a deceased group. The demographics, clinical characteristics, disease-related severity, and prognosis were analyzed. Results: Of the included patients, there were 40 male and 22 female, the median age at onset was 53.2 years. The median diagnosis time was 13.1 months and median follow-up duration was 18.5 months; 72.6% of patients presented with spinal onset ALS, and 27.4% with bulbar-onset. There were 20 deaths during follow-up, and the median survival time in the deceased cases was 14 months. Worse prognosis factors were bulbar symptoms at onset and low amyotrophic lateral sclerosis functional rating scale (ALSFRS) at diagnosis. Conclusion: The factors associated with lower survival in ALS patients were bulbar symptoms at onset and low ALSFRS at diagnosis.

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泰国一组肌萎缩性脊髓侧索硬化症患者的临床特征和预后

背景与目的：肌萎缩侧索硬化症（ALS）患者的临床病程和预后变化很大。有关泰国人群的信息仍然缺乏。本研究旨在确定泰国 ALS 患者疾病进展的临床关联和预后因素。研究方法这项前瞻性队列研究评估了 2014 年 1 月至 2018 年 12 月期间在泰国神经研究所随访的 62 名确诊为 ALS 的患者。这些患者被分为存活组和死亡组。研究人员对这些患者的人口统计学特征、临床特征、疾病相关严重程度和预后进行了分析。结果显示在纳入的患者中，男性 40 人，女性 22 人，中位发病年龄为 53.2 岁。中位确诊时间为 13.1 个月，中位随访时间为 18.5 个月；72.6% 的患者为脊髓型 ALS 发病，27.4% 为球部发病。随访期间有20人死亡，死亡病例的中位生存时间为14个月。预后较差的因素是发病时出现球部症状和确诊时肌萎缩侧索硬化症功能评分量表（ALSFRS）较低。结论是肌萎缩侧索硬化症患者存活率较低的相关因素是发病时出现球部症状和确诊时ALSFRS较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Asia CLINICAL NEUROLOGY-

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Neurology Asia (ISSN 1823-6138), previously known as Neurological Journal of South East Asia (ISSN 1394-780X), is the official journal of the ASEAN Neurological Association (ASNA), Asian & Oceanian Association of Neurology (AOAN), and the Asian & Oceanian Child Neurology Association. The primary purpose is to publish the results of study and research in neurology, with emphasis to neurological diseases occurring primarily in Asia, aspects of the diseases peculiar to Asia, and practices of neurology in Asia (Asian neurology).