Posterior Segment Optical Coherence Tomography: An Adjunctive Tool in Monitoring Voriconazole Treatment of Fungal Chorioretinitis

Abstract

: Background: Early management of fungal chorioretinitis is necessary to improve the visual prognosis. Purpose : To evaluate the role of posterior segment optical coherence tomography (PS-OCT) in the management of fungal chorioretinitis. Patients and Methods : It is a case series of 5 eyes of 3 participants with fungal chorioretinitis. The diagnosis was established clinically and by PS-OCT. All participants were subjected to a complete ophthalmic examination and PS-OCT. Participants received loading 6mg/kg/12 hours intravenous voriconazole for 24 hours then a cycle of an oral voriconazole 200 mg twice daily for 4 weeks. Results: At 6 months follow-up, BCVA improved from 1.15 ± 0.28 to 0.30 ± 0.09 LogMAR. The mean duration of the treatment was 4.3±1.5 weeks. Follow-up OCT images demonstrated decreased size of chorioretinal lesions and complete resolution at 6-months follow-up. Neither ocular nor systemic complications were reported during the follow-up period. Conclusion : PS-OCT may give an objective tool for systemic antifungal treatments of fungal chorioretinitis assessing the disease progression, monitor therapeutic response, and achieving good functional and anatomical outcomes in our study cohort.