Evaluation of Cardiac Reserve Using Echocardiography for The Detection of Mild Cardiac Dysfunction in Mice - A Review

Abstract

Assessing cardiac reserve in mice through echocardiography is essential for early detection of subtle cardiac issues and understanding potential treatments. Despite challenges such as precise measurements, strain imaging stress-based cardiac reserve assessment (SIS-CRA) is used in this study, providing insights into the heart's functional capacity by measuring myocardial deformation and contractility. This technique aids in identifying cardiac abnormalities early, allowing for timely interventions. Stress echocardiography is particularly valuable in heart failure and cardiotoxicity studies, where cardiac reserve plays a crucial role. Beyond diagnostics, this review explores applications in cardiovascular medicine and drug discovery, highlighting the method's revolutionary potential. Simulation analysis is incorporated to showcase its capability to improve research techniques and contribute to the detection of heart failure in mouse models.