Review of Asprosin as new Biomarker for diagnosis different Diseases

Safaa Ehssan, Baydaa Ahmed Abed, Isam Noori Salman, Lujain A. Ghannawi
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Abstract

This study was designed to investigate the connections between (Inflammation, Cardiovascular diseases (CVDs),-diabetes mellitus,-Obesity,-polycystic ovary syndrome, thyroid and cancer )-and asprosin hormone. Asprosin is present in high amounts in a variety of diseases that are considerably manifested in several cases and illnesses Asprosin hormone is newly adipokine helps the liver produce glucose. White adipose tissue secretes the novel hormone asprosin, which stimulates the release of hepatic glucose, making protein a possible target for new treatments for obesity and  type 2 diabetes mellitus. Exons (65 and 66) of the gene( Fibrillin 1 (FBN1)), which was recently shown to be a new hormone released by white adipose tissues, are the final two exons that code for asprosin. However, further research is needed to fully understand how asprosin affects pancreatic beta-cells, leading to pathologically elevated cellular dysfunction and inflammation. Asprosin hormone is raised  in human  with metabolic disease. The findings imply that asprosin hormone  may be crucial for maintaining insulin and glucose homeostasis as well as acting as a risk factor for a number of diseases, including CVDs, obesity,  T2DM, cancer, hypothyroidism, and PCOS. Depleting asprosin or attenuating its activity may potentially offer a novel therapeutic option for the treatment of T2DM and obesity.
将阿司匹林作为诊断不同疾病的新生物标记物的综述
本研究旨在探讨(炎症、心血管疾病(CVDs)、糖尿病、肥胖、多囊卵巢综合征、甲状腺和癌症)与芦荟素激素之间的联系。阿司匹林大量存在于多种疾病中,这些疾病主要表现为多种病例和疾病 阿司匹林激素是一种新的脂肪因子,可帮助肝脏产生葡萄糖。白色脂肪组织会分泌一种新的激素--asprosin,它能刺激肝脏释放葡萄糖,使蛋白质成为肥胖症和 2 型糖尿病新疗法的可能靶点。最近被证明是由白色脂肪组织释放的一种新荷尔蒙的基因(纤连蛋白 1 (FBN1))的外显子(65 和 66)是编码阿司匹林的最后两个外显子。然而,要充分了解阿司匹林如何影响胰腺β细胞,导致细胞功能障碍和炎症的病理性升高,还需要进一步的研究。患有代谢性疾病的人体内的阿司匹林激素会升高。研究结果表明,胰岛素激素对维持胰岛素和葡萄糖稳态至关重要,同时也是心血管疾病、肥胖症、T2DM、癌症、甲状腺功能减退症和多囊卵巢综合症等多种疾病的风险因素。消耗asprosin或削弱其活性有可能为治疗T2DM和肥胖症提供一种新的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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