Danshen-Chuanxiongqin Injection for Enhanced Management of Neurological Function in Elderly Patients with Acute Ischemic Stroke

Abstract

This study investigates the pharmacological properties of Danshen-Chuanxiongqin Injection and the impact of an evidence-based nursing model based on an innovative diffusion theory framework on neurological function in elderly patients with acute ischemic stroke. The stability of the injection was assessed via ultra-high-performance liquid chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry. The pharmacological properties of the injection were evaluated in three groups of rats: Group A (Cold coagulation and blood stasis), Group B (Blood stasis with sthenia), and Group C (Normal control). Groups A and B were further divided into subgroups receiving either physiological saline or the injection, followed by an analysis of hemorheological parameters. 200 elderly patients with acute ischemic stroke were divided into two groups: a control group (evidence-based nursing model based on the innovative diffusion theory framework) and an observation group (Danshen-Chuanxiongqin Injection+evidence-based nursing model based on the innovative diffusion theory framework). Medication quality was confirmed using SPSS 26.0. In animal experiments, Group B displayed improved hemorheology, adverse drug reaction, and thyroidstimulating hormone levels (P < 0.05). The observation group exhibited reduced post-treatment plasma renin activity, angiotensin II, aldosterone, and norepinephrine. At the treatment end and 6-month follow-up, the observation group showed significantly improved neurological function (P < 0.05). The injection demonstrated stable pharmacological properties with a cooling effect, effectively treating blood stasis with sthenia-related symptoms. The evidence-based nursing model with the innovative diffusion theory framework effectively enhanced neurological function, neuroendocrine hormones, clinical efficacy, and safety in elderly patients with acute ischemic stroke. This approach holds promise for further implementation and promotion.