Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics

IF 5.9 Q1 MICROBIOLOGY

Biofilm Pub Date : 2024-01-01 DOI:10.1016/j.bioflm.2023.100175

Xiying Wu , Huan Wang , Juan Xiong , Guo-Xun Yang , Jin-Feng Hu , Quangang Zhu , Zhongjian Chen

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引用次数: 0

Abstract

Staphylococcus aureus can readily form biofilm which enhances the drug-resistance, resulting in life-threatening infections involving different organs. Biofilm formation occurs due to a series of developmental events including bacterial adhesion, aggregation, biofilm maturation, and dispersion, which are controlled by multiple regulatory systems. Rapidly increasing research and development outcomes on natural products targeting S. aureus biofilm formation and/or regulation led to an emergent application of active phytochemicals and combinations. This review aimed at providing an in-depth understanding of biofilm formation and regulation mechanisms for S. aureus, outlining the most important antibiofilm strategies and potential targets of natural products, and summarizing the latest progress in combating S. aureus biofilm with plant-derived natural products. These findings provided further evidence for novel antibiofilm drugs research and clinical therapies.

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金黄色葡萄球菌生物膜：配方、监管和新兴天然产品疗法

金黄色葡萄球菌很容易形成生物膜，从而增强耐药性，导致涉及不同器官的危及生命的感染。生物膜的形成是一系列发育过程的结果，包括细菌粘附、聚集、生物膜成熟和分散，这些过程受多种调节系统控制。针对金黄色葡萄球菌生物膜形成和/或调控的天然产品的研发成果迅速增加，导致活性植物化学物质及其组合的应用不断涌现。本综述旨在深入了解金黄色葡萄球菌生物膜的形成和调控机制，概述最重要的抗生物膜策略和天然产物的潜在靶点，并总结利用植物源天然产物抗击金黄色葡萄球菌生物膜的最新进展。这些发现为新型抗生物膜药物研究和临床疗法提供了进一步的证据。

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来源期刊

Biofilm MICROBIOLOGY-

CiteScore

7.50

自引率

1.50%

发文量

审稿时长

57 days

期刊介绍：