Tertiary lymphoid structures in tongue cancer: Association with clinicopathological parameters, preoperative S-1 chemotherapy response, and prognosis

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2024-01-06 DOI:10.1111/jop.13509

Mai Seki, Takaaki Sano, Emi Saito, Masaru Ogawa, Satoshi Yokoo, Tetsunari Oyama

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引用次数: 0

Abstract

Background

Tertiary lymphoid structures (TLSs) are observed in cancer-invasive sites of various organs, and show evidence of tumor-specific B and/or T cells, suggesting an active humoral antitumor response. The aim of this study was to evaluate the relationship between TLSs and prognosis in patients with tongue squamous cell carcinoma (TSCC) after preoperative S-1 chemotherapy.

Methods

Among 196 TSCC cases, 111 patients who received preoperative S-1 chemotherapy were compared to 85 patients who did not receive chemotherapy. We investigated the incidence of TLSs in both preoperative biopsy and resected specimens.

Results

TLSs were present in 24 (12%) biopsy specimens and 31 (16%) resected specimens. TLSs were associated with clinicopathologically advanced cases and positivity for lymphatic invasion. None of the cases with pStage 0 (i.e., noninvasive cancer) showed TLSs. In preoperative S-1 chemotherapy cases, TLSs were significantly more common in those treated with S-1 for more than 21 days and in those with treatment effects 0, Ia, and Ib. TLSs may not be a favorable prognostic factor by themselves but maybe a prognostic factor when combined with preoperative S-1 treatment.

Conclusion

The presence of TLSs was suggested to be a factor indicating a favorable prognosis when considering the indication for preoperative S-1 chemotherapy. The synergistic effect of S-1 by activating antitumor immunity may be associated with a better prognosis in TSCC patients with TLSs.

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舌癌的三级淋巴结构：与临床病理参数、术前 S-1 化疗反应和预后的关系

背景：三级淋巴结构（TLSs）可在不同器官的癌症浸润部位观察到，并显示出肿瘤特异性B细胞和/或T细胞的证据，表明体液抗肿瘤反应活跃。本研究旨在评估舌鳞状细胞癌（TSCC）患者术前S-1化疗后TLS与预后之间的关系：在196例TSCC患者中，111例接受了术前S-1化疗，85例未接受化疗。我们调查了术前活检和切除标本中TLS的发生率：结果：24 例（12%）活检标本和 31 例（16%）切除标本中出现了 TLS。TLS与临床病理晚期病例和淋巴侵犯阳性有关。p阶段为0（即非浸润性癌症）的病例中没有一个出现TLS。在术前接受 S-1 化疗的病例中，S-1 治疗时间超过 21 天的病例以及治疗效果为 0、Ia 和 Ib 的病例出现 TLS 的比例明显更高。TLS本身可能不是一个有利的预后因素，但如果与术前S-1治疗相结合，则可能是一个预后因素：结论：在考虑术前 S-1 化疗的适应症时，TLS 的存在被认为是预后良好的一个因素。S-1通过激活抗肿瘤免疫而产生的协同效应可能与伴有TLSs的TSCC患者预后较好有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.