{"title":"Cells, pathways, and models in dyskinesia research","authors":"M. Angela Cenci , Arvind Kumar","doi":"10.1016/j.conb.2023.102833","DOIUrl":null,"url":null,"abstract":"<div><p>L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic movement disorder resulting from altered information processing in the cortico-basal ganglia network. We here review recent advances clarifying the altered interplay between striatal output pathways in this movement disorder. We also review studies revealing structural and synaptic changes to the striatal microcircuitry and altered cortico-striatal activity dynamics in LID. We furthermore highlight the recent progress made in understanding the involvement of cerebellar and brain stem nuclei. These recent developments illustrate that dyskinesia research continues to provide key insights into cellular and circuit-level plasticity within the cortico-basal ganglia network and its interconnected brain regions.</p></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"84 ","pages":"Article 102833"},"PeriodicalIF":4.8000,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959438823001587/pdfft?md5=1fc19c40cf009b4addde527983f2d31e&pid=1-s2.0-S0959438823001587-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959438823001587","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic movement disorder resulting from altered information processing in the cortico-basal ganglia network. We here review recent advances clarifying the altered interplay between striatal output pathways in this movement disorder. We also review studies revealing structural and synaptic changes to the striatal microcircuitry and altered cortico-striatal activity dynamics in LID. We furthermore highlight the recent progress made in understanding the involvement of cerebellar and brain stem nuclei. These recent developments illustrate that dyskinesia research continues to provide key insights into cellular and circuit-level plasticity within the cortico-basal ganglia network and its interconnected brain regions.
左旋多巴诱导的运动障碍（LID）是一种最常见的过度运动障碍，是由于皮质-基底节网络的信息处理发生了改变。我们在此回顾了阐明这种运动障碍中纹状体输出通路之间相互作用改变的最新进展。我们还回顾了揭示 LID 中纹状体微电路结构和突触变化以及皮质-纹状体活动动态改变的研究。此外，我们还重点介绍了在了解小脑和脑干核团的参与方面所取得的最新进展。这些最新进展表明，运动障碍研究将继续为了解皮质-基底节网络及其相互连接的脑区的细胞和回路级可塑性提供重要见解。
期刊介绍：
Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance.
The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives.
Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories:
-Neurobiology of Disease-
Neurobiology of Behavior-
Cellular Neuroscience-
Systems Neuroscience-
Developmental Neuroscience-
Neurobiology of Learning and Plasticity-
Molecular Neuroscience-
Computational Neuroscience
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