Microbial transmission in the social microbiome and host health and disease.

IF 5.7 1区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Chemical Theory and Computation Pub Date : 2024-01-04 DOI:10.1016/j.cell.2023.12.014

Amar Sarkar, Cameron J A McInroy, Siobhán Harty, Aura Raulo, Neil G O Ibata, Mireia Valles-Colomer, Katerina V-A Johnson, Ilana L Brito, Joseph Henrich, Elizabeth A Archie, Luis B Barreiro, Francesca S Gazzaniga, B Brett Finlay, Eugene V Koonin, Rachel N Carmody, Andrew H Moeller

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引用次数: 0

Abstract

Although social interactions are known to drive pathogen transmission, the contributions of socially transmissible host-associated mutualists and commensals to host health and disease remain poorly explored. We use the concept of the social microbiome-the microbial metacommunity of a social network of hosts-to analyze the implications of social microbial transmission for host health and disease. We investigate the contributions of socially transmissible microbes to both eco-evolutionary microbiome community processes (colonization resistance, the evolution of virulence, and reactions to ecological disturbance) and microbial transmission-based processes (transmission of microbes with metabolic and immune effects, inter-specific transmission, transmission of antibiotic-resistant microbes, and transmission of viruses). We consider the implications of social microbial transmission for communicable and non-communicable diseases and evaluate the importance of a socially transmissible component underlying canonically non-communicable diseases. The social transmission of mutualists and commensals may play a significant, under-appreciated role in the social determinants of health and may act as a hidden force in social evolution.

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社会微生物群中的微生物传播与宿主的健康和疾病。

尽管众所周知社会互动是病原体传播的驱动力，但与宿主相关的社会传播互生菌和共生菌对宿主健康和疾病的贡献仍然鲜为人知。我们利用社会微生物组--宿主社会网络的微生物元群落--的概念来分析社会微生物传播对宿主健康和疾病的影响。我们研究了社会传播微生物对微生物群落生态进化过程（定植抵抗、毒力进化和对生态干扰的反应）和基于微生物传播的过程（具有代谢和免疫效应的微生物传播、种间传播、抗生素耐药微生物传播和病毒传播）的贡献。我们考虑了社会微生物传播对传染性和非传染性疾病的影响，并评估了非传染性疾病中社会传播因素的重要性。互生和共生微生物的社会传播可能在健康的社会决定因素中发挥着重要的、未被充分认识的作用，并可能成为社会进化中的一种隐性力量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Theory and Computation 化学-物理：原子、分子和化学物理

CiteScore

9.90

自引率

16.40%

发文量

568

审稿时长

1 months

期刊介绍： The Journal of Chemical Theory and Computation invites new and original contributions with the understanding that, if accepted, they will not be published elsewhere. Papers reporting new theories, methodology, and/or important applications in quantum electronic structure, molecular dynamics, and statistical mechanics are appropriate for submission to this Journal. Specific topics include advances in or applications of ab initio quantum mechanics, density functional theory, design and properties of new materials, surface science, Monte Carlo simulations, solvation models, QM/MM calculations, biomolecular structure prediction, and molecular dynamics in the broadest sense including gas-phase dynamics, ab initio dynamics, biomolecular dynamics, and protein folding. The Journal does not consider papers that are straightforward applications of known methods including DFT and molecular dynamics. The Journal favors submissions that include advances in theory or methodology with applications to compelling problems.