Zhi-Jie Wang , Lin-Lin Tan , Yu Zhang , Jia-Qi Yan , Jian-Ping Liu
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引用次数: 0
Abstract
Introduction
Human immunodeficiency virus (HIV) has spread globally. Both acquired immune deficiency syndromes (AIDs) and its complications pose a serious threat to human health. Acupuncture has been reported as a complement to Western medicine for relieving HIV/AIDs-related symptoms, but systematic reviews on acupuncture for HIV/AIDs and its complications are lacking.
Methods
Six databases were searched for both randomized controlled trials (RCTs) and quasi-randomized controlled trials (q-RCTs) using any types of acupuncture for HIV/AIDs and their complications. The primary outcome included global clinical efficacy assessment (i.e., number of patients with improving symptoms), pain, numbness intensity, sleep quality, depression and severe adverse events (i.e., death or hospitalization), and the secondary outcomes included other HIV/AIDs related outcomes such as immune response markers (CD4+ T-lymphocyte count), biochemical markers, functional outcomes (quality of life, level of physical activity), follow-ups and other adverse outcomes such as nausea, vomiting, and fever. Two reviewers independently applied the inclusion criteria, extracted data and evaluated the risk of bias in the included trials. This systematic review is registered with PROSPERO (CRD42020214490).
Results
Sixteen trials (thirteen RCTs and three q-RCTs) on complications including peripheral neuropathy, gastrointestinal symptoms, inflammation, insomnia and depression were included. The results revealed that manual acupuncture plus moxibustion (RR 1.58, 95 % CI [1.10, 2.28], 1 RCT, n = 60), manual acupuncture only (RR 1.56, 95 % CI [1.20, 2.03], 1 RCT, 1 q-RCT, n = 175) or auricular acupuncture (RR 2.02, 95 % CI [1.35, 3.02], 1 RCT, n = 72) could improve the symptoms in HIV-infected patients; reduce pain and numbness intensity, reduce score of Hamilton Depression Scale andimprove sleep quality. Meanwhile, acupuncture appeared to improve biochemical indicators whilst not increasing the drop-out rate, recurrence, mortality or adverse events. The quality of evidence was moderate quality for sleep quality; low quality for global clinical efficacy assessment rate, pain and numbness intensity; and very low quality for pain and depression.
Conclusions
Acupuncture may be an effective and safe intervention for HIV/AIDs related complications, including peripheral neuropathy, inflammation, insomnia and depression. However, the low quality of the evidence limits the relevance of those findings.
期刊介绍:
The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education.
EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians.
The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.