The effects of L-carnitine supplementation on lipid profiles in adults: A systematic review and dose-response meta-analysis

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition Pub Date : 2023-12-23 DOI:10.1016/j.phanu.2023.100374

Sina Raissi Dehkordi , Mahsa Malekahmadi , Mahlagha Nikbaf-Shandiz , Niloufar Rasaei , Amir Mehdi Hosseini , Hossein Bahari , Samira Rastgoo , Omid Asbaghi , Farideh Shiraseb , Reza Behmadi

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引用次数: 0

Abstract

Background

We aimed to conduct this meta-analysis to systematically assess the effects of L-carnitine supplementation on levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), total cholesterol (TC), Apolipoprotein A (Apo A) and Apolipoprotein B (Apo B) in adults.

Methods

A systematic search was done in databases such as PubMed, ISI Web of Science, the Cochrane Library, and Scopus to find acceptable articles up to April 2023. Randomized controlled trials (RCTs) evaluating the effects of L-carnitine on lipid profiles in adults were included considering the specified inclusion and exclusion criteria.

Results

We included the 60 RCTs (n = 3933) with 64 effect sizes in this study. L-carnitine supplementation had a significant effect on TG (WMD= −10.33 mg/dl, P < 0.001), TC (WMD= −6.91 mg/dl, P = 0.032), LDL-C (WMD= −7.51 mg/dl, P < 0.001), HDL-C (WMD= 1.80 mg/dl, P = 0.007) in intervention, compared to a placebo group, in the pooled analysis. Moreover, we conducted the subgroup analyses that have shown L-carnitine supplementation had a reduction effect on TG in baseline ≥ 150 mg/dl, and in any trial duration (<12 and ≥12 weeks), intervention dose ≥ 2 g/day, in overweight (25–29.9 kg/m²) and obese (>30 kg/m²), in type ² diabetes and other health status. Also, L-carnitine significantly impacted TC in baseline ≥ 200 mg/dl, trial duration ≥ 12 weeks, intervention dose ≥ 2 g/day, obese (>30 kg/m²), and other health statuses.

Conclusions

Our results indicate L-carnitine significantly reduces the serum levels of TC, LDL-C, and TG and increases HDL-C, but it had no significant effect on the levels of apolipoproteins.

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补充左旋肉碱对成年人血脂状况的影响：系统综述和剂量反应荟萃分析

背景我们旨在进行这项荟萃分析，系统评估补充左旋肉碱对成人低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、总胆固醇（TC）、载脂蛋白A（载脂蛋白A）和载脂蛋白B（载脂蛋白B）水平的影响。方法在 PubMed、ISI Web of Science、Cochrane Library 和 Scopus 等数据库中进行系统检索，以找到截至 2023 年 4 月可接受的文章。根据规定的纳入和排除标准，纳入了评估左旋肉碱对成人血脂状况影响的随机对照试验（RCT）。在汇总分析中，与安慰剂组相比，补充左旋肉碱对干预组的 TG（WMD= -10.33 mg/dl，P = 0.001）、TC（WMD= -6.91 mg/dl，P = 0.032）、LDL-C（WMD= -7.51 mg/dl，P = 0.001）、HDL-C（WMD= 1.80 mg/dl，P = 0.007）有显著影响。此外，我们还进行了亚组分析，结果表明，在基线≥150 mg/dl、任何试验持续时间（12 周和≥12 周）、干预剂量≥2 g/天、超重（25-29.9 kg/m2）和肥胖（30 kg/m2）、2 型糖尿病和其他健康状况下，补充左旋肉碱都有降低血脂的作用。此外，左旋肉碱对基线≥200 mg/dl、试验持续时间≥12周、干预剂量≥2 g/天、肥胖（30 kg/m2）和其他健康状况的人群的总胆固醇有明显影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PharmaNutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.70

自引率

3.10%

发文量

审稿时长

12 days