Comprehensive Genomic Characterization of Antibiotic Resistance, Virulence, and Clonality in Salmonella Isolates from Wild Animals in Algeria.

IF 2.2 3区环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES

Ecohealth Pub Date : 2023-12-01 Epub Date: 2024-01-04 DOI:10.1007/s10393-023-01670-7

Zahra Bellil, Sylvain Meyer, Valentin Tilloy, Assia Mairi, Olivier Barraud, Christophe De Champs, Abdelaziz Touati

引用次数: 0

Abstract

This study investigated Salmonella spp. in wild animals in Algeria, focusing on their prevalence, serotypes, antibiotic resistance, and virulence profiles. From fecal samples collected between May 2021 and June 2022, 1.9% showed Salmonella shedding. The identified serotypes included S. Bredeney, S. Enteritidis, S. Altona, and S. Virchow. Except for S. Altona, all isolates were resistant to quinolones, with S. Bredeney strains, exhibiting multidrug resistance. Whole-genome sequencing revealed various resistance genes and mutations in gyrA or parC genes. Additionally, plasmids IncX1 and ColpVC were detected in several isolates. A comprehensive analysis identified 201 virulence genes. These findings contribute to understanding Salmonella in wild animal populations and their potential impact on public health.

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阿尔及利亚野生动物沙门氏菌对抗生素的耐药性、毒性和克隆性的综合基因组特征。

本研究调查了阿尔及利亚野生动物中的沙门氏菌属，重点关注其流行率、血清型、抗生素耐药性和毒力特征。在 2021 年 5 月至 2022 年 6 月期间采集的粪便样本中，1.9% 的样本显示有沙门氏菌脱落。已确定的血清型包括 S. Bredeney、S. Enteritidis、S. Altona 和 S. Virchow。除阿尔托纳沙门氏菌外，所有分离菌株均对喹诺酮类药物具有耐药性，其中布雷德尼沙门氏菌菌株对多种药物具有耐药性。全基因组测序发现了各种耐药基因以及 gyrA 或 parC 基因的突变。此外，在几个分离株中检测到了质粒 IncX1 和 ColpVC。综合分析确定了 201 个毒力基因。这些发现有助于了解野生动物种群中的沙门氏菌及其对公共卫生的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ecohealth 环境科学-环境科学

CiteScore

4.50

自引率

4.00%

发文量

审稿时长

>24 weeks

期刊介绍： EcoHealth aims to advance research, practice, and knowledge integration at the interface of ecology and health by publishing high quality research and review articles that address and profile new ideas, developments, and programs. The journal’s scope encompasses research that integrates concepts and theory from many fields of scholarship (including ecological, social and health sciences, and the humanities) and draws upon multiple types of knowledge, including those of relevance to practice and policy. Papers address integrated ecology and health challenges arising in public health, human and veterinary medicine, conservation and ecosystem management, rural and urban development and planning, and other fields that address the social-ecological context of health. The journal is a central platform for fulfilling the mission of the EcoHealth Alliance to strive for sustainable health of people, domestic animals, wildlife, and ecosystems by promoting discovery, understanding, and transdisciplinarity. The journal invites substantial contributions in the following areas: One Health and Conservation Medicine o Integrated research on health of humans, wildlife, livestock and ecosystems o Research and policy in ecology, public health, and agricultural sustainability o Emerging infectious diseases affecting people, wildlife, domestic animals, and plants o Research and practice linking human and animal health and/or social-ecological systems o Anthropogenic environmental change and drivers of disease emergence in humans, wildlife, livestock and ecosystems o Health of humans and animals in relation to terrestrial, freshwater, and marine ecosystems Ecosystem Approaches to Health o Systems thinking and social-ecological systems in relation to health o Transdiiplinary approaches to health, ecosystems and society.