Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Human Hypertension Pub Date : 2024-01-04 DOI:10.1038/s41371-023-00889-9

Ran Sun, Yali Li, Lei Lv, Weiliang Zhang, Xiaoxia Guo

引用次数: 0

Abstract

This study aimed to assess the efficacy and safety of esaxerenone (CS-3150) in treating primary hypertension. PubMed (Medline), Cochrane Central Register of Controlled Trials (CENTRAL), and Embase databases were searched for articles published until April 18, 2023. The outcomes included were diastolic blood pressure (DBP), systolic blood pressure (SBP), 24 h DBP, 24 h SBP, and adverse events. The meta-analysis was conducted using RevMan 5.3. This study included three trials. CS-3150 5 mg had a greater effect on lowering the SBP, DBP, 24 h SBP, and 24 h DBP than either CS-3150 2.5 mg or eplerenone 50 mg. In contrast, CS-3150 2.5 mg and eplerenone 50 mg showed no significant difference in lowering DBP, SBP, 24 h DBP, and 24 h SBP. Moreover, adverse events occurred at comparable rates in the three groups. CS-3150 (especially CS-3150 5 mg) is an effective and safe treatment for primary hypertension; which can reduce blood pressure and alleviate hypertensive symptoms.

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埃沙塞酮（CS-3150）对原发性高血压的疗效和安全性：一项荟萃分析。

本研究旨在评估埃沙塞酮（CS-3150）治疗原发性高血压的疗效和安全性。研究人员在PubMed（Medline）、Cochrane对照试验中央注册中心（CENTRAL）和Embase数据库中检索了截至2023年4月18日发表的文章。结果包括舒张压 (DBP)、收缩压 (SBP)、24 h DBP、24 h SBP 和不良事件。荟萃分析使用 RevMan 5.3 进行。该研究包括三项试验。与 CS-3150 2.5 毫克或依普利酮 50 毫克相比，CS-3150 5 毫克对降低 SBP、DBP、24 小时 SBP 和 24 小时 DBP 的效果更好。相比之下，CS-3150 2.5 毫克和依普利酮 50 毫克在降低 DBP、SBP、24 小时 DBP 和 24 小时 SBP 方面没有显著差异。此外，三组的不良反应发生率相当。CS-3150（尤其是 CS-3150 5 毫克）是一种有效、安全的原发性高血压治疗药物，可降低血压并缓解高血压症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Hypertension 医学-外周血管病

CiteScore

5.20

自引率

3.70%

发文量

126

审稿时长

6-12 weeks

期刊介绍： Journal of Human Hypertension is published monthly and is of interest to health care professionals who deal with hypertension (specialists, internists, primary care physicians) and public health workers. We believe that our patients benefit from robust scientific data that are based on well conducted clinical trials. We also believe that basic sciences are the foundations on which we build our knowledge of clinical conditions and their management. Towards this end, although we are primarily a clinical based journal, we also welcome suitable basic sciences studies that promote our understanding of human hypertension. The journal aims to perform the dual role of increasing knowledge in the field of high blood pressure as well as improving the standard of care of patients. The editors will consider for publication all suitable papers dealing directly or indirectly with clinical aspects of hypertension, including but not limited to epidemiology, pathophysiology, therapeutics and basic sciences involving human subjects or tissues. We also consider papers from all specialties such as ophthalmology, cardiology, nephrology, obstetrics and stroke medicine that deal with the various aspects of hypertension and its complications.