Normative Values for Serum Neurofilament Light Chain in US Adults.

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Clinical Neurology Pub Date : 2024-01-01 DOI:10.3988/jcn.2022.0340

Thomas A Beltran

{"title":"Normative Values for Serum Neurofilament Light Chain in US Adults.","authors":"Thomas A Beltran","doi":"10.3988/jcn.2022.0340","DOIUrl":null,"url":null,"abstract":"Background and purpose: Neurofilament light chain (NfL) levels serve as a marker of neuroaxonal injury and can be measured in both cerebrospinal fluid and serum. Although serum NfL (sNfL) levels have been shown to increase with the progression of various neurological conditions, normative values for healthy individuals have not yet been established. This study was undertaken to determine age-specific normative values for sNfL and evaluate the associations between sNfL and sociodemographic characteristics.Methods: A retrospective analysis was conducted using population-based data collected by the National Health and Nutrition Examination Survey between 2013 and 2014. The sera of 2071 adult participants were collected. General linear models were used to examine the associations between sNfL levels and sample characteristics.Results: The data analysis revealed a significant positive association between age and sNfL levels (p<0.001). Sex was also associated with sNfL levels (p=0.04) after controlling for age. The mean sNfL levels for males and females were 17.99 pg/mL (95% confidence interval [CI]=15.43-20.17) and 15.78 pg/mL (95% CI=13.00-18.55) respectively, after controlling for age.Conclusions: These results suggest that sNfL levels increase with age and are affected by sex. The findings of this study provide a useful baseline for comparing sNfL levels in clinical practice and future research.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"20 1","pages":"46-49"},"PeriodicalIF":2.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782095/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3988/jcn.2022.0340","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and purpose: Neurofilament light chain (NfL) levels serve as a marker of neuroaxonal injury and can be measured in both cerebrospinal fluid and serum. Although serum NfL (sNfL) levels have been shown to increase with the progression of various neurological conditions, normative values for healthy individuals have not yet been established. This study was undertaken to determine age-specific normative values for sNfL and evaluate the associations between sNfL and sociodemographic characteristics.

Methods: A retrospective analysis was conducted using population-based data collected by the National Health and Nutrition Examination Survey between 2013 and 2014. The sera of 2071 adult participants were collected. General linear models were used to examine the associations between sNfL levels and sample characteristics.

Results: The data analysis revealed a significant positive association between age and sNfL levels (p<0.001). Sex was also associated with sNfL levels (p=0.04) after controlling for age. The mean sNfL levels for males and females were 17.99 pg/mL (95% confidence interval [CI]=15.43-20.17) and 15.78 pg/mL (95% CI=13.00-18.55) respectively, after controlling for age.

Conclusions: These results suggest that sNfL levels increase with age and are affected by sex. The findings of this study provide a useful baseline for comparing sNfL levels in clinical practice and future research.

查看原文本刊更多论文

美国成年人血清神经丝轻链的标准值。

背景和目的：神经丝蛋白轻链（NfL）水平是神经轴突损伤的标志物，可在脑脊液和血清中测定。虽然血清 NfL（sNfL）水平已被证明会随着各种神经系统疾病的进展而升高，但健康人的正常值尚未确定。本研究旨在确定特定年龄的 sNfL 标准值，并评估 sNfL 与社会人口特征之间的关联：方法：利用 2013 年至 2014 年间美国国家健康与营养调查收集的人群数据进行了一项回顾性分析。收集了 2071 名成年参与者的血清。采用一般线性模型研究 sNfL 水平与样本特征之间的关联：数据分析显示，在控制年龄后，年龄与 sNfL 水平之间存在明显的正相关关系（pp=0.04）。控制年龄后，男性和女性的平均 sNfL 水平分别为 17.99 pg/mL（95% 置信区间 [CI]=15.43-20.17）和 15.78 pg/mL（95% CI=13.00-18.55）：这些结果表明，sNfL水平随着年龄的增长而增加，并受性别影响。本研究结果为临床实践和未来研究中比较 sNfL 水平提供了有用的基准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Neurology 医学-临床神经学

CiteScore

4.50

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The JCN aims to publish the cutting-edge research from around the world. The JCN covers clinical and translational research for physicians and researchers in the field of neurology. Encompassing the entire neurological diseases, our main focus is on the common disorders including stroke, epilepsy, Parkinson''s disease, dementia, multiple sclerosis, headache, and peripheral neuropathy. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, and letters to the editor. The JCN will allow clinical neurologists to enrich their knowledge of patient management, education, and clinical or experimental research, and hence their professionalism.