Response to: regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI:10.1007/s12026-023-09452-7
Sabiha Anis, Mariam Ashfaq Khan, Areej Fatima, Fatima Kanani, Javeria Aijaz, Aneela Hussain, Samreen Sarfaraz
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引用次数: 0

Abstract

In response to Chen et al.'s comments on our paper regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection in vaccinated patients, we have highlighted the role and the scope of this paper in this correspondence. The role of anti-COVID-19-IgA is already known. The objective of the previous study was to see its role in breakthrough-infected patients. To analyse this effect, we recruited patients with COVID-19 infection after they were fully vaccinated and compared them with the vaccinated group who did not get the infection. Both groups were equally exposed to the virus as all of them were health care workers. We also showed that the anti-COVID-19-NP-IgA was absent in the healthy cohort of our study groups, signifying the absence of natural infection in them during this period. The article also highlights the importance of vaccinating all individuals including those who are immunosuppressed, as it prevents severe COVID-19 infection in these individuals. The physicians should be aware of the fact that immunosuppressed patients are more likely to get COVID-19 breakthrough infection. However, proper vaccination with booster doses prevents severe infection in them.

回复:关于 COVID-19 突破性感染中抗 COVID-IgA 抗体反应的意义。
针对 Chen 等人对我们论文中关于抗 COVID-IgA 抗体反应在接种疫苗的患者中 COVID-19 突破性感染中的意义的评论,我们在这封信函中强调了这篇论文的作用和范围。抗 COVID-19-IgA 的作用已众所周知。之前研究的目的是了解其在突破性感染患者中的作用。为了分析这种作用,我们招募了接种完全疫苗后感染 COVID-19 的患者,并将他们与未感染 COVID-19 的接种组进行比较。由于两组患者都是医护人员,因此他们接触病毒的机会相同。我们还发现,在我们研究小组的健康人群中没有抗 COVID-19-NP-IgA,这表明他们在此期间没有自然感染。文章还强调了为包括免疫抑制者在内的所有人接种疫苗的重要性,因为这可以预防这些人感染严重的 COVID-19。医生应该意识到,免疫抑制患者更容易感染 COVID-19。不过,适当接种加强剂量的疫苗可以防止他们受到严重感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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