Benign breast disease and breast cancer risk in African women: a case-control study.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Causes & Control Pub Date : 2024-05-01 Epub Date: 2024-01-05 DOI:10.1007/s10552-023-01837-1

Olasubomi J Omoleye, Jincong Q Freeman, Mojisola Oluwasanu, Adenike Adeniji-Sofoluwe, Anna E Woodard, Benjamin S Aribisala, Prisca O Adejumo, Atara Ntekim, Timothy Makumbi, Paul Ndom, IkeOluwapo O Ajayi, Olufunmilayo I Olopade, Dezheng Huo

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引用次数: 0

Abstract

Purpose: To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.

Methods: BC cases and controls were enrolled in three sub-Saharan African countries, Nigeria, Cameroon, and Uganda, between 1998 and 2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD.

Results: Of 6,274 participants, 55.6% (3,478) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most commonly reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] 1.47, 95% CI 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR 2.25, 95% CI 1.26-4.02). BBD did not significantly mediate the effects of any of the selected BC risk factors.

Conclusions: In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.

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非洲妇女的良性乳腺疾病与乳腺癌风险：一项病例对照研究。

目的：研究非洲女性异质性人群中良性乳腺疾病（BBD）与乳腺癌（BC）之间的关联：1998年至2018年期间，在三个撒哈拉以南非洲国家（尼日利亚、喀麦隆和乌干达）招募了乳腺癌病例和对照组。采用多变量逻辑回归法检验BBD与BC之间的关联。选择了与BBD和BC双重相关的风险因素。利用参数中介分析模型，我们评估了所选的 BC 风险因素是否受到 BBD 的中介作用：在 6274 名参与者中，55.6%（3478 人）为乳腺癌病例。360人（5.7%）自述患有BBD。纤维腺瘤（46.8%）是最常报告的 BBD。自述有 BBD 病史的妇女比没有 BBD 病史的妇女患 BC 的几率更高（调整后的几率比 [aOR] 1.47，95% CI 1.13-1.91）。活组织检查证实 BBD 与 BC 相关（aOR 2.25，95% CI 1.26-4.02）。BBD对任何选定的BC风险因素的影响都没有明显的中介作用：在这项研究中，BBD与BC相关，但对选定的BC风险因素的影响没有明显的中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.