Associations between dry eye disease and sleep quality: a cross-sectional analysis.

IF 2 Q2 OPHTHALMOLOGY
Mohammad Ayoubi, Kimberly Cabrera, Simran Mangwani, Elyana Vittoria Tessa Locatelli, Anat Galor
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引用次数: 0

Abstract

Background/aims: To investigate relationships between dry eye (DE) disease and sleep quality, with a focus on which aspects of sleep most closely relate to DE.

Methods: 141 veterans (mean age: 56±5) seen at the Miami Veterans Affairs eye clinic filled out questionnaires to quantify the severity of DE symptoms (5-Item Dry Eye Questionnaire (DEQ-5) and Ocular Surface Disease Index (OSDI)) and ocular pain (Numerical Rating Scale (NRS) and Neuropathic Pain Symptom Inventory modified for the Eye (NPSI-E)). All individuals also underwent an ocular surface examination. Aspects of sleep quality were assessed using the Pittsburgh Sleep Quality Index (PSQI). DE metrics were examined by PSQI scores and subscores.

Results: Most participants (76%) reported mild or greater DE symptoms (DEQ-5 ≥6). Overall, ocular symptoms were more related to sleep metrics than signs. The strongest DE symptom association was between the OSDI and sleep disturbances (PSQI subscore 5, r=0.49, p<0.0005). For DE signs, ocular surface inflammation and meibum quality were related to subjective sleep quality (PSQI subscore 1, r=0.29, p=0.03, for both). On linear regression analyses, most ocular symptom questionnaires remained associated with sleep disturbances (PSQI subscore 5: NRS (r=0.52, p<0.0005), DEQ-5 (r=0.36, p<0.0005), and OSDI (r=0.31, p<0.0005)). For DE signs, ocular surface inflammation and meibum quality remained associated with subjective sleep quality (r=0.26, p=0.01; r=0.46, p<0.0005, respectively).

Conclusion: DE symptom and ocular pain intensity were closely related to sleep metrics, most strongly to sleep disturbances. Relationships were weaker for DE signs, with subjective sleep quality relating to inflammation and meibum quality.

干眼症与睡眠质量之间的关系:横断面分析。
背景/目的:方法:在迈阿密退伍军人事务眼科诊所就诊的 141 名退伍军人(平均年龄:56±5 岁)填写了调查问卷,以量化干眼症状(5 项干眼症状问卷 (DEQ-5) 和眼表疾病指数 (OSDI))和眼部疼痛(数字评分量表 (NRS) 和眼部神经性疼痛症状量表 (NPSI-E))的严重程度。所有患者还接受了眼表检查。睡眠质量采用匹兹堡睡眠质量指数(PSQI)进行评估。通过 PSQI 分数和子分对 DE 指标进行检查:结果:大多数参与者(76%)报告了轻度或更严重的 DE 症状(DEQ-5 ≥6)。总体而言,眼部症状与睡眠指标的关系大于体征。眼部疼痛症状与睡眠指标的关系最密切的是OSDI和睡眠障碍(PSQI子分数5,r=0.49,p):DE 症状和眼部疼痛强度与睡眠指标密切相关,其中与睡眠障碍的关系最为密切。DE 征兆的关系较弱,主观睡眠质量与炎症和眼睑质量有关。
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来源期刊
BMJ Open Ophthalmology
BMJ Open Ophthalmology OPHTHALMOLOGY-
CiteScore
3.40
自引率
4.20%
发文量
104
审稿时长
20 weeks
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