Molecular skin fluorescence imaging: A tool for evaluating early melanoma development

IF 3.9 3区医学 Q2 CELL BIOLOGY

Pigment Cell & Melanoma Research Pub Date : 2024-01-04 DOI:10.1111/pcmr.13159

Amit Shachaf, Kevin Manbeck, Guang Yang, Catherine Shachaf

引用次数: 0

Abstract

A novel approach to melanoma diagnosis—in vivo molecular skin fluorescence imaging (mSFI)—was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% specificity, while identifying dysplastic nevi with the potential for melanoma development.

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分子皮肤荧光成像：评估早期黑色素瘤发展的工具。

我们开发了一种诊断黑色素瘤的新方法--体内分子皮肤荧光成像（mSFI）--通过对病变近端微环境成像，以组织重塑的形式识别与人类黑色素瘤发展相关的恶性前变化。该方法使用一种与αvβ3整合素结合的荧光肽（ORL-1）进行测试，αvβ3整合素是一种与黑色素瘤浸润性发展相关的分子。结果表明，7 分的临界值能以 100% 的灵敏度和 95.7% 的特异性将黑色素瘤与非黑色素瘤痣区分开来，同时还能识别出有可能发展成黑色素瘤的发育不良痣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pigment Cell & Melanoma Research 医学-皮肤病学

CiteScore

8.90

自引率

2.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders