Mechanobiology of myeloid cells

IF 6 2区 生物学 Q1 CELL BIOLOGY
Eline Janssen , Koen van den Dries , Maurizio Ventre , Alessandra Cambi
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引用次数: 0

Abstract

Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti-inflammatory phenotype. This is especially relevant in the context of altered matrix mechanics in immune-related pathologies or in the response to implanted biomaterials. A detailed understanding of myeloid cell mechanosensing may eventually lead to more effective cell-based immunotherapies for cancer, the development of mechanically inspired therapies to target fibrosis, and the engineering of safer implants. This review covers these recent advances in the emerging field of mechanoimmunology of myeloid cells.

髓系细胞的机械生物学
组织驻留的髓样细胞能感知和传递机械信号,如硬度、拉伸和压缩。在过去两年中,我们对髓系细胞中机械敏感信号通路的了解有了显著扩展。此外,哪些机械信号会诱导髓系细胞形成促炎或抗炎表型也越来越清楚。这与免疫相关病症中基质力学的改变或对植入生物材料的反应尤为相关。对髓系细胞机械传感的详细了解可能最终会带来更有效的癌症细胞免疫疗法、针对纤维化的机械启发疗法的开发以及更安全植入物的工程设计。本综述将介绍髓系细胞机械免疫学这一新兴领域的最新进展。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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