Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

IF 4.3 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress Pub Date : 2024-01-04 DOI:10.1016/j.ynstr.2024.100605

Laurel R. Seemiller , Julio Flores-Cuadra , Keith R. Griffith , Grace C. Smith , Nicole A. Crowley

引用次数: 0

Abstract

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.

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在人的一生中，酒精和压力是导致阿尔茨海默病和认知能力下降的关键风险因素

阿尔茨海默病和相关痴呆症（ADRD）对全球健康计划的威胁与日俱增。要预防阿尔茨海默病和相关痴呆症的发生，除了要了解增加和减少神经变性和认知能力下降风险的行为外，还需要揭示这些影响背后的生物机制。压力暴露和饮酒都与人类 ADRD 风险的增加有关。然而，我们要了解 ADRD 的因果机制，还需要大量的临床前研究。在本综述中，我们总结了现有的人类和动物研究，这些研究调查了终生压力暴露和酒精暴露与 ADRD 之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

9.40

自引率

4.00%

发文量

审稿时长

48 days

期刊介绍： Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.