Bioactive polymers for cosmetics: unleashing the potential of Chromohalobacter canadensis 28

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2024-01-03 DOI:10.1007/s13233-023-00236-4

Merve Erginer, Songül Yaşar Yıldız, Margarita Kambourova, Ebru Toksoy Öner

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Abstract

The growing demand for natural products in the cosmetic industry has led to increased interest in natural polysaccharides that offer biocompatibility, biodegradability, and bioactivity. Microorganisms have emerged as a promising source for large-scale production of these polysaccharides under controlled conditions. Among them, the halophilic bacterium Chromohalobacter canadensis 28 stands out as it produces an exopolymer (Cc EP) consisting of exopolysaccharides (EPS) and poly-gamma-glutamic acid (γ-PGA), making it the first halophilic microorganism known for PGA production. This study explores the potential of crude Cc EP and purified γ-PGA for improving the skin barrier, stimulating collagen and hyaluronic acid production, and facilitating wound closure. Through in-vitro experiments using human epidermal keratinocyte cells (HaCaT) and dermal fibroblast cells (PCS-201-012), both the exopolymers were found to exhibit positive effects on cellular proliferation and the expression of genes related to collagen, hyaluronic acid, involucrin, and filaggrin. Furthermore, in-vitro scratch models demonstrated their ability to enhance wound closure. Based on these promising findings, we propose that Cc EP and purified γ-PGA hold potential as active ingredients in cosmeceutical products. Their ability to promote cell proliferation, improve collagen and hyaluronic acid expression, and enhance wound closure makes them valuable assets for skincare applications.

Graphical abstract

Production and effect of Chromohalobacter canadensis 28 exopolymer on human skin cells

Abstract Image

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用于化妆品的生物活性聚合物：释放罐头色杆菌的潜力 28

摘要随着化妆品行业对天然产品的需求日益增长，人们对具有生物相容性、生物可降解性和生物活性的天然多糖越来越感兴趣。微生物已成为在可控条件下大规模生产这些多糖的一个有前途的来源。其中，嗜卤细菌 Chromohalobacter canadensis 28 尤为突出，因为它能产生一种由外多糖（EPS）和聚γ-谷氨酸（γ-PGA）组成的外多聚物（Cc EP），是已知的第一种能生产 PGA 的嗜卤微生物。本研究探讨了粗Cc EP和纯化的γ-PGA在改善皮肤屏障、刺激胶原蛋白和透明质酸生成以及促进伤口闭合方面的潜力。通过使用人类表皮角质细胞（HaCaT）和真皮成纤维细胞（PCS-201-012）进行体外实验，发现这两种外聚合物对细胞增殖以及胶原蛋白、透明质酸、内含蛋白和丝胶蛋白相关基因的表达均有积极影响。此外，体外划痕模型也证明了它们具有促进伤口闭合的能力。基于这些充满希望的研究结果，我们认为 Cc EP 和纯化的 γ-PGA 有潜力成为化妆品中的活性成分。它们具有促进细胞增殖、改善胶原蛋白和透明质酸表达以及增强伤口闭合的能力，是护肤品应用中的宝贵资产。图文并茂的摘要犬色杆菌 28 外聚合物的生产及其对人类皮肤细胞的影响

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.