Improving cellular diversity in human cerebellar organoids

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-01-04 DOI:10.1016/j.stem.2023.12.007

Marilyn Steyert, Tomasz Nowakowski

引用次数: 0

Abstract

The developing human cerebellum has a greater diversity of progenitor types than that of the mouse, necessitating a human-based model for studying cerebellar development and disease. Atamian et al.¹ developed a 3D organoid model of cerebellar development, which recapitulates many cell types found in the developing human cerebellum, including Purkinje-neuron-like cells.

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提高人类小脑器官组织的细胞多样性

与小鼠相比，发育中的人类小脑具有更多样化的祖细胞类型，因此需要一个基于人类的模型来研究小脑发育和疾病。Atamian等人1开发了一种小脑发育的三维类器官模型，该模型再现了发育中的人类小脑中的许多细胞类型，包括浦肯野神经元样细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.