Evaluation of breast skin and tissue stiffness using a non-invasive aspiration device and impact of clinical predictors

IF 2.3 4区 医学 Q1 ANATOMY & MORPHOLOGY
Clinical Anatomy Pub Date : 2024-01-04 DOI:10.1002/ca.24134
Martha Duraes, Noemie Briot, Nathanael Connesson, Gregory Chagnon, Yohan Payan, Claire Duflos, Gauthier Rathat, Guillaume Captier, Gerard Subsol, Christian Herlin
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Abstract

A personalized 3D breast model could present a real benefit for preoperative discussion with patients, surgical planning, and guidance. Breast tissue biomechanical properties have been poorly studied in vivo, although they are important for breast deformation simulation. The main objective of our study was to determine breast skin thickness and breast skin and adipose/fibroglandular tissue stiffness. The secondary objective was to assess clinical predictors of elasticity and thickness: age, smoking status, body mass index, contraception, pregnancies, breastfeeding, menopausal status, history of radiotherapy or breast surgery. Participants were included at the Montpellier University Breast Surgery Department from March to May 2022. Breast skin thickness was measured by ultrasonography, breast skin and adipose/fibroglandular tissue stiffnesses were determined with a VLASTIC non-invasive aspiration device at three different sites (breast segments I–III). Multivariable linear models were used to assess clinical predictors of elasticity and thickness. In this cohort of 196 women, the mean breast skin and adipose/fibroglandular tissue stiffness values were 39 and 3 kPa, respectively. The mean breast skin thickness was 1.83 mm. Only menopausal status was significantly correlated with breast skin thickness and adipose/fibroglandular tissue stiffness. The next step will be to implement these stiffness and thickness values in a biomechanical breast model and to evaluate its capacity to predict breast tissue deformations.

Abstract Image

使用无创抽吸装置评估乳房皮肤和组织硬度以及临床预测因素的影响。
个性化三维乳房模型可为患者术前讨论、手术规划和指导带来真正的好处。虽然乳房组织的生物力学特性对乳房变形模拟很重要,但对其进行的体内研究却很少。我们研究的主要目的是确定乳房皮肤厚度以及乳房皮肤和脂肪/纤维腺组织的硬度。次要目标是评估弹性和厚度的临床预测因素:年龄、吸烟状况、体重指数、避孕、怀孕、哺乳、绝经状况、放疗或乳房手术史。参与者于 2022 年 3 月至 5 月在蒙彼利埃大学乳腺外科就诊。乳房皮肤厚度通过超声波检查测量,乳房皮肤和脂肪/纤维腺组织硬度通过VLASTIC无创抽吸装置在三个不同部位(乳房I-III段)测定。采用多变量线性模型评估弹性和厚度的临床预测因素。在这组 196 名女性中,乳房皮肤和脂肪/纤维腺组织的平均硬度值分别为 39 千帕和 3 千帕。平均乳房皮肤厚度为 1.83 毫米。只有绝经状态与乳房皮肤厚度和脂肪/纤维腺组织硬度有明显的相关性。下一步将在乳房生物力学模型中应用这些硬度和厚度值,并评估其预测乳房组织变形的能力。
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来源期刊
Clinical Anatomy
Clinical Anatomy 医学-解剖学与形态学
CiteScore
5.50
自引率
12.50%
发文量
154
审稿时长
3 months
期刊介绍: Clinical Anatomy is the Official Journal of the American Association of Clinical Anatomists and the British Association of Clinical Anatomists. The goal of Clinical Anatomy is to provide a medium for the exchange of current information between anatomists and clinicians. This journal embraces anatomy in all its aspects as applied to medical practice. Furthermore, the journal assists physicians and other health care providers in keeping abreast of new methodologies for patient management and informs educators of new developments in clinical anatomy and teaching techniques. Clinical Anatomy publishes original and review articles of scientific, clinical, and educational interest. Papers covering the application of anatomic principles to the solution of clinical problems and/or the application of clinical observations to expand anatomic knowledge are welcomed.
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