Association of birth weight with risk of diabetes mellitus in adolescence and early adulthood: analysis of the Indonesian Family Life Survey.

IF 2.8 Q3 ENDOCRINOLOGY & METABOLISM

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI:10.6065/apem.2346146.073

Ratu Ayu Dewi Sartika, Fathimah Sulistyowati Sigit, Edy Purwanto, Norliyana Aris, Avliya Quratul Marjan, Wahyu Kurnia Yusrin Putra, Sutanto Priyo Hastono

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引用次数: 0

Abstract

Purpose: We aimed to investigate the association of birth weight with the risk of diabetes mellitus in adolescence and early adulthood in the Indonesian population.

Methods: This study analyzed data from the Indonesian Family Life Survey, a longitudinal study of the Indonesian population with repeated measurements at 3 time points (1997, 2007, and 2014). The subjects observed were children aged 0-59 months in 1997, who were 10-15 years old in 2007, and 17-22 years in 2014. We performed a generalized linear model to investigate the association between birth weight at baseline and the level of hemoglobin A1c (HbA1c) at the 2 follow-up periods. We adjusted the association for the characteristics of the children, parents, and household.

Results: The mean±standard deviation level of HbA1c was 7.35%±0.95% in 2007 and decreased to 5.30%±0.85% in 2014. The crude β (95% confidence interval [CI]) of the association between birth weight and HbA1c was 0.150 (-0.076, 0.377) in 2007 and 0.146 (-0.060, 0.351) in 2014. After adjustment for the sociodemographic characteristics of the children, parents, and confounding factors, the adjusted β (95% CI) was 1.12 (0.40-1.85) in 2007 and 0.92 (0.35-1.48) in 2014. The HbA1c of the parents, father's employment status, percentage of food expenditure, and underweight were the covariates that had significant associations with HbA1c.

Conclusion: HbA1c level was higher in adolescence than in early adulthood. Birth weight was associated with HbA1c level in both periods. The HbA1c of the parents, father's employment, percentage of food expenditure, and underweight partly explained the association between birth weight and the HbA1c level.

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出生体重与青春期和成年早期糖尿病风险的关系：印度尼西亚家庭生活调查分析。

目的：我们旨在研究出生体重与印度尼西亚人口青春期和成年早期糖尿病风险的关系：本研究分析了印度尼西亚家庭生活调查的数据，该调查是印度尼西亚人口的一项纵向研究，在三个时间点（1997 年、2007 年和 2014 年）进行重复测量。观察对象为 1997 年 0-59 个月大的儿童，2007 年为 10-15 岁，2014 年为 17-22 岁。我们采用广义线性模型研究了基线出生体重与两个随访期血红蛋白 A1c（HbA1c）水平之间的关系。我们对儿童、父母和家庭的特征进行了调整：2007年，HbA1c的平均值（含标准差）为7.35%±0.95%，2014年降至5.30%±0.85%。出生体重与 HbA1c 之间关系的粗略 β 值（95% 置信区间 [CI]）在 2007 年为 0.150（-0.076, 0.377），在 2014 年为 0.146（-0.060, 0.351）。在对儿童、父母的社会人口特征和混杂因素进行调整后，调整后的β（95% CI）在2007年为1.12（0.40-1.85），在2014年为0.92（0.35-1.48）。父母的 HbA1c、父亲的就业状况、食品支出比例和体重不足是与 HbA1c 有显著关联的协变量：结论：青少年时期的 HbA1c 水平高于成年早期。结论：青少年时期的 HbA1c 水平高于成年早期，出生体重与这两个时期的 HbA1c 水平都有关系。父母的 HbA1c、父亲的就业情况、食品支出比例和体重不足在一定程度上解释了出生体重与 HbA1c 水平之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Pediatric Endocrinology & Metabolism Multiple-

CiteScore

4.00

自引率

18.20%

发文量

审稿时长

24 weeks

期刊介绍： The Annals of Pediatric Endocrinology & Metabolism Journal is the official publication of the Korean Society of Pediatric Endocrinology. Its formal abbreviated title is “Ann Pediatr Endocrinol Metab”. It is a peer-reviewed open access journal of medicine published in English. The journal was launched in 1996 under the title of ‘Journal of Korean Society of Pediatric Endocrinology’ until 2011 (pISSN 1226-2242). Since 2012, the title is now changed to ‘Annals of Pediatric Endocrinology & Metabolism’. The Journal is published four times per year on the last day of March, June, September, and December. It is widely distributed for free to members of the Korean Society of Pediatric Endocrinology, medical schools, libraries, and academic institutions. The journal is indexed/tracked/covered by web sites of PubMed Central, PubMed, Emerging Sources Citation Index (ESCI), Scopus, EBSCO, EMBASE, KoreaMed, KoMCI, KCI, Science Central, DOI/CrossRef, Directory of Open Access Journals(DOAJ), and Google Scholar. The aims of Annals of Pediatric Endocrinology & Metabolism are to contribute to the advancements in the fields of pediatric endocrinology & metabolism through the scientific reviews and interchange of all of pediatric endocrinology and metabolism. It aims to reflect the latest clinical, translational, and basic research trends from worldwide valuable achievements. In addition, genome research, epidemiology, public education and clinical practice guidelines in each country are welcomed for publication. The Journal particularly focuses on research conducted with Asian-Pacific children whose genetic and environmental backgrounds are different from those of the Western. Area of specific interest include the following : Growth, puberty, glucose metabolism including diabetes mellitus, obesity, nutrition, disorders of sexual development, pituitary, thyroid, parathyroid, adrenal cortex, bone or other endocrine and metabolic disorders from infancy through adolescence.