Smooth Pursuit and Reflexive Saccade in Discriminating Multiple-System Atrophy With Predominant Parkinsonism From Parkinson's Disease.

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-01 DOI:10.3988/jcn.2022.0413

Yaqin Yu, Jinyu Wang, Lihong Si, Huanxin Sun, Xiaolei Liu, Xinyi Li, Weihong Yan

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引用次数: 0

Abstract

Background and purpose: Performing the differential diagnosis of Parkinson's disease (PD) and multiple-system atrophy of parkinsonian type (MSA-P) is challenging. The oculomotor performances of patients with PD and MSA-P were investigated to explore their potential role as a biomarker for this differentiation.

Methods: Reflexive saccades and smooth pursuit were examined in 56 patients with PD and 34 with MSA-P in the off-medication state.

Results: Patients with PD and MSA-P had similar oculomotor abnormalities of prolonged and hypometric reflexive saccades. The incidence rates of decreased reflexive saccadic velocity and saccadic smooth pursuit were significantly higher in MSA-P than in PD (p<0.05 for both). Multiple logistic regression analysis indicated that slowed reflexive saccades (odds ratio [OR]=8.14, 95% confidence interval [CI]=1.45-45.5) and saccadic smooth pursuit (OR=5.27, 95% CI=1.24-22.43) were significantly related to MSA-P.

Conclusions: The distinctive oculomotor abnormalities of saccadic smooth pursuit and slowed reflexive saccades in MSA-P may serve as useful biomarkers for discriminating MSA-P from PD.

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平滑追逐和反射性回旋在鉴别多系统萎缩伴帕金森症和帕金森病中的作用

背景和目的：对帕金森病（PD）和帕金森型多系统萎缩（MSA-P）进行鉴别诊断具有挑战性。研究人员对帕金森病和帕金森型多系统萎缩患者的眼球运动表现进行了调查，以探索它们作为这种鉴别的生物标志物的潜在作用：方法：研究人员对 56 名帕金森氏症患者和 34 名 MSA-P 患者在非用药状态下的反射性眼球运动和平滑追逐运动进行了检测：结果：帕金森氏症患者和MSA-P患者具有相似的眼球运动异常，即反射性眼球移动时间过长和反射性眼球移动次数过少。MSA-P患者反射性追视速度和追视平稳性降低的发生率明显高于帕金森病患者（p结论：帕金森病患者和MSA-P患者的眼球运动异常特征相似，但MSA-P患者的反射性追视速度和追视平稳性降低的发生率明显高于帕金森病患者：MSA-P患者的眼球运动异常表现为眼球平滑追逐和反射性眼球转动速度减慢，这可能是鉴别MSA-P和帕金森病的有用生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neurology 医学-临床神经学

CiteScore

4.50

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The JCN aims to publish the cutting-edge research from around the world. The JCN covers clinical and translational research for physicians and researchers in the field of neurology. Encompassing the entire neurological diseases, our main focus is on the common disorders including stroke, epilepsy, Parkinson''s disease, dementia, multiple sclerosis, headache, and peripheral neuropathy. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, and letters to the editor. The JCN will allow clinical neurologists to enrich their knowledge of patient management, education, and clinical or experimental research, and hence their professionalism.